Tumor necrosis factor receptor superfamily member 9
Intermolecular
Cysteine 121 and cysteine 121
Cysteine 64 and cysteine 44
Intramolecular
Cysteine 139 and cysteine 253
Cysteine 139 and cysteine 158
Cysteine 121 and cysteine 45
Cysteine 28 and cysteine 37
Cysteine 65 and cysteine 78
Cysteine 106 and cysteine 117
Cysteine 48 and cysteine 62
Cysteine 31 and cysteine 45
More...Cysteine 68 and cysteine 86
Cysteine 28 and cysteine 37
Cysteine 88 and cysteine 102
Cysteine 120 and cysteine 133
Cysteine 94 and cysteine 99
Cysteine 88 and cysteine 99
Cysteine 28 and cysteine 31
Cysteine 88 and cysteine 94
Cysteine 61 and cysteine 77
Cysteine 31 and cysteine 37
Cysteine 37 and cysteine 45
Cysteine 99 and cysteine 102
Cysteine 94 and cysteine 102
Cysteine 28 and cysteine 31
Cysteine 121 and cysteine 37
Cysteine 28 and cysteine 45
Cysteine 86 and cysteine 99
Cysteine 48 and cysteine 65
Cysteine 117 and cysteine 133
Cysteine 68 and cysteine 94
Cysteine 121 and cysteine 62
Cysteine 45 and cysteine 48
Cysteine 48 and cysteine 78
Cysteine 106 and cysteine 133
Cysteine 68 and cysteine 78
Cysteine 106 and cysteine 120
Cysteine 68 and cysteine 102
Cysteine 120 and cysteine 121
Cysteine 121 and cysteine 48
Cysteine 86 and cysteine 102
6a3w I 121 L 121
A redox-regulated disulphide may form between two units of Tumor necrosis factor receptor superfamily member 9 at cysteines 121 and 121.
Details
Redox score ?
78
PDB code
6a3w
Structure name
complex structure of 4-1bb and utomilumab
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tumor necrosis factor receptor superfamily member 9
Peptide B name
Tumor necrosis factor receptor superfamily member 9
Peptide A accession
Q07011
Peptide B accession
Q07011
Peptide A residue number
121
Peptide B residue number
121
Ligandability
5wi8 B 64 D 44
A redox-regulated disulphide may form between two units of Tumor necrosis factor receptor superfamily member 9 at cysteines 64 and 44. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
5wi8
Structure name
crystal structure of murine 4-1bb from hek293t cells in p21 space group
Structure deposition date
2017-07-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Tumor necrosis factor receptor superfamily member 9
Peptide B name
Tumor necrosis factor receptor superfamily member 9
Peptide A accession
P20334
Peptide B accession
P20334
Peptide A residue number
64
Peptide B residue number
44
Ligandability
Cysteine 64 of Tumor necrosis factor receptor superfamily member 9
Cysteine 44 of Tumor necrosis factor receptor superfamily member 9
6cu0 K 139 K 158
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 139 and 253 (139 and 158 respectively in this structure).
Details
Redox score ?
91
PDB code
6cu0
Structure name
crystal structure of 4-1bbl/4-1bb (c121s) complex in p21 space group
Structure deposition date
2018-03-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
139
Residue number B
253
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 139 of Tumor necrosis factor receptor superfamily member 9
Cysteine 253 of Tumor necrosis factor receptor superfamily member 9
6a3v B 139 B 158
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 139 and 158.
Details
Redox score ?
90
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
139
Residue number B
158
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 139 of Tumor necrosis factor receptor superfamily member 9
Cysteine 158 of Tumor necrosis factor receptor superfamily member 9
6cu0 L 31 L 45
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 121 and 45 (31 and 45 respectively in this structure).
Details
Redox score ?
89
PDB code
6cu0
Structure name
crystal structure of 4-1bbl/4-1bb (c121s) complex in p21 space group
Structure deposition date
2018-03-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
121
Residue number B
45
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 121 of Tumor necrosis factor receptor superfamily member 9
Cysteine 45 of Tumor necrosis factor receptor superfamily member 9
5wi8 B 28 B 37
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 28 and 37.
Details
Redox score ?
88
PDB code
5wi8
Structure name
crystal structure of murine 4-1bb from hek293t cells in p21 space group
Structure deposition date
2017-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20334
Residue number A
28
Residue number B
37
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 28 of Tumor necrosis factor receptor superfamily member 9
Cysteine 37 of Tumor necrosis factor receptor superfamily member 9
6a3v J 65 J 78
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 65 and 78.
Details
Redox score ?
88
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
65
Residue number B
78
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 65 of Tumor necrosis factor receptor superfamily member 9
Cysteine 78 of Tumor necrosis factor receptor superfamily member 9
6a3v B 106 B 117
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 106 and 117.
Details
Redox score ?
87
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
106
Residue number B
117
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 106 of Tumor necrosis factor receptor superfamily member 9
Cysteine 117 of Tumor necrosis factor receptor superfamily member 9
6a3v X 48 X 62
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 48 and 62.
Details
Redox score ?
87
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
48
Residue number B
62
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 48 of Tumor necrosis factor receptor superfamily member 9
Cysteine 62 of Tumor necrosis factor receptor superfamily member 9
6mhr C 31 C 45
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 31 and 45.
Details
Redox score ?
86
PDB code
6mhr
Structure name
structure of the human 4-1bb / urelumab fab complex
Structure deposition date
2018-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
31
Residue number B
45
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 31 of Tumor necrosis factor receptor superfamily member 9
Cysteine 45 of Tumor necrosis factor receptor superfamily member 9
6a3v T 68 T 86
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 68 and 86.
Details
Redox score ?
85
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
68
Residue number B
86
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 68 of Tumor necrosis factor receptor superfamily member 9
Cysteine 86 of Tumor necrosis factor receptor superfamily member 9
6cu0 H 28 H 37
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 28 and 37.
Details
Redox score ?
85
PDB code
6cu0
Structure name
crystal structure of 4-1bbl/4-1bb (c121s) complex in p21 space group
Structure deposition date
2018-03-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
28
Residue number B
37
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 28 of Tumor necrosis factor receptor superfamily member 9
Cysteine 37 of Tumor necrosis factor receptor superfamily member 9
6a3w F 88 F 102
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 88 and 102.
Details
Redox score ?
85
PDB code
6a3w
Structure name
complex structure of 4-1bb and utomilumab
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
88
Residue number B
102
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 88 of Tumor necrosis factor receptor superfamily member 9
Cysteine 102 of Tumor necrosis factor receptor superfamily member 9
6a3w I 120 I 133
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 120 and 133.
Details
Redox score ?
85
PDB code
6a3w
Structure name
complex structure of 4-1bb and utomilumab
Structure deposition date
2018-06-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
120
Residue number B
133
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 120 of Tumor necrosis factor receptor superfamily member 9
Cysteine 133 of Tumor necrosis factor receptor superfamily member 9
6mi2 F 94 F 99
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 94 and 99.
Details
Redox score ?
84
PDB code
6mi2
Structure name
structure of the human 4-1bb / utomilumab fab complex
Structure deposition date
2018-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
94
Residue number B
99
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 94 of Tumor necrosis factor receptor superfamily member 9
Cysteine 99 of Tumor necrosis factor receptor superfamily member 9
6mi2 C 88 C 99
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 88 and 99.
Details
Redox score ?
76
PDB code
6mi2
Structure name
structure of the human 4-1bb / utomilumab fab complex
Structure deposition date
2018-09-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
88
Residue number B
99
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 88 of Tumor necrosis factor receptor superfamily member 9
Cysteine 99 of Tumor necrosis factor receptor superfamily member 9
6mkz D 28 D 31
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 28 and 31.
Details
Redox score ?
74
PDB code
6mkz
Structure name
crystal structure of murine 4-1bb/4-1bbl complex
Structure deposition date
2018-09-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20334
Residue number A
28
Residue number B
31
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 28 of Tumor necrosis factor receptor superfamily member 9
Cysteine 31 of Tumor necrosis factor receptor superfamily member 9
6cu0 L 88 L 94
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 88 and 94.
Details
Redox score ?
73
PDB code
6cu0
Structure name
crystal structure of 4-1bbl/4-1bb (c121s) complex in p21 space group
Structure deposition date
2018-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
88
Residue number B
94
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 88 of Tumor necrosis factor receptor superfamily member 9
Cysteine 94 of Tumor necrosis factor receptor superfamily member 9
5wiw B 61 B 77
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 61 and 77.
Details
Redox score ?
72
PDB code
5wiw
Structure name
crystal structure of murine 4-1bb n128a mutant from hek293t cells in p43 space group
Structure deposition date
2017-07-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P20334
Residue number A
61
Residue number B
77
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 61 of Tumor necrosis factor receptor superfamily member 9
Cysteine 77 of Tumor necrosis factor receptor superfamily member 9
6bwv D 31 D 37
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 31 and 37.
Details
Redox score ?
72
PDB code
6bwv
Structure name
crystal structure of the 4-1bb/4-1bbl complex
Structure deposition date
2017-12-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
31
Residue number B
37
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 31 of Tumor necrosis factor receptor superfamily member 9
Cysteine 37 of Tumor necrosis factor receptor superfamily member 9
6a3v X 37 X 45
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 37 and 45.
Details
Redox score ?
72
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
37
Residue number B
45
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 37 of Tumor necrosis factor receptor superfamily member 9
Cysteine 45 of Tumor necrosis factor receptor superfamily member 9
6a3w I 99 I 102
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 99 and 102.
Details
Redox score ?
70
PDB code
6a3w
Structure name
complex structure of 4-1bb and utomilumab
Structure deposition date
2018-06-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
99
Residue number B
102
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 99 of Tumor necrosis factor receptor superfamily member 9
Cysteine 102 of Tumor necrosis factor receptor superfamily member 9
6a3v V 94 V 102
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 94 and 102.
Details
Redox score ?
68
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
94
Residue number B
102
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 94 of Tumor necrosis factor receptor superfamily member 9
Cysteine 102 of Tumor necrosis factor receptor superfamily member 9
6mgp X 28 X 31
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 28 and 31.
Details
Redox score ?
68
PDB code
6mgp
Structure name
structure of human 4-1bb / 4-1bbl complex
Structure deposition date
2018-09-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
28
Residue number B
31
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 28 of Tumor necrosis factor receptor superfamily member 9
Cysteine 31 of Tumor necrosis factor receptor superfamily member 9
6cu0 L 31 L 37
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 121 and 37 (31 and 37 respectively in this structure).
Details
Redox score ?
67
PDB code
6cu0
Structure name
crystal structure of 4-1bbl/4-1bb (c121s) complex in p21 space group
Structure deposition date
2018-03-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q07011
Residue number A
121
Residue number B
37
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 121 of Tumor necrosis factor receptor superfamily member 9
Cysteine 37 of Tumor necrosis factor receptor superfamily member 9
6mgp Z 28 Z 45
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 28 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
6mgp
Structure name
structure of human 4-1bb / 4-1bbl complex
Structure deposition date
2018-09-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
28
Residue number B
45
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 28 of Tumor necrosis factor receptor superfamily member 9
Cysteine 45 of Tumor necrosis factor receptor superfamily member 9
6a3w F 86 F 99
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 86 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6a3w
Structure name
complex structure of 4-1bb and utomilumab
Structure deposition date
2018-06-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
86
Residue number B
99
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 86 of Tumor necrosis factor receptor superfamily member 9
Cysteine 99 of Tumor necrosis factor receptor superfamily member 9
6mi2 F 48 F 65
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 48 and 65. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6mi2
Structure name
structure of the human 4-1bb / utomilumab fab complex
Structure deposition date
2018-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
48
Residue number B
65
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 48 of Tumor necrosis factor receptor superfamily member 9
Cysteine 65 of Tumor necrosis factor receptor superfamily member 9
6a3v T 117 T 133
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 117 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
117
Residue number B
133
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 117 of Tumor necrosis factor receptor superfamily member 9
Cysteine 133 of Tumor necrosis factor receptor superfamily member 9
6mhr C 68 C 94
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 68 and 94. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6mhr
Structure name
structure of the human 4-1bb / urelumab fab complex
Structure deposition date
2018-09-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
68
Residue number B
94
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 68 of Tumor necrosis factor receptor superfamily member 9
Cysteine 94 of Tumor necrosis factor receptor superfamily member 9
6cu0 L 31 L 62
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 121 and 62 (31 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6cu0
Structure name
crystal structure of 4-1bbl/4-1bb (c121s) complex in p21 space group
Structure deposition date
2018-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
121
Residue number B
62
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 121 of Tumor necrosis factor receptor superfamily member 9
Cysteine 62 of Tumor necrosis factor receptor superfamily member 9
6a3v J 45 J 48
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 45 and 48. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6a3v
Structure name
complex structure of human 4-1bb and 4-1bbl
Structure deposition date
2018-06-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q07011
Residue number A
45
Residue number B
48
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 45 of Tumor necrosis factor receptor superfamily member 9
Cysteine 48 of Tumor necrosis factor receptor superfamily member 9
6cpr D 48 D 78
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 48 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6cpr
Structure name
crystal structure of 4-1bbl/4-1bb complex in c2 space group
Structure deposition date
2018-03-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
48
Residue number B
78
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 48 of Tumor necrosis factor receptor superfamily member 9
Cysteine 78 of Tumor necrosis factor receptor superfamily member 9
6mhr C 106 C 133
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 106 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6mhr
Structure name
structure of the human 4-1bb / urelumab fab complex
Structure deposition date
2018-09-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
106
Residue number B
133
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 106 of Tumor necrosis factor receptor superfamily member 9
Cysteine 133 of Tumor necrosis factor receptor superfamily member 9
6mhr F 68 F 78
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 68 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6mhr
Structure name
structure of the human 4-1bb / urelumab fab complex
Structure deposition date
2018-09-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
68
Residue number B
78
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 68 of Tumor necrosis factor receptor superfamily member 9
Cysteine 78 of Tumor necrosis factor receptor superfamily member 9
6mi2 F 106 F 120
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 106 and 120. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6mi2
Structure name
structure of the human 4-1bb / utomilumab fab complex
Structure deposition date
2018-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
106
Residue number B
120
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 106 of Tumor necrosis factor receptor superfamily member 9
Cysteine 120 of Tumor necrosis factor receptor superfamily member 9
6mi2 F 68 F 102
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 68 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6mi2
Structure name
structure of the human 4-1bb / utomilumab fab complex
Structure deposition date
2018-09-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
68
Residue number B
102
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 68 of Tumor necrosis factor receptor superfamily member 9
Cysteine 102 of Tumor necrosis factor receptor superfamily member 9
6cpr E 120 E 121
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 120 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6cpr
Structure name
crystal structure of 4-1bbl/4-1bb complex in c2 space group
Structure deposition date
2018-03-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
nan
Peptide accession
Q07011
Residue number A
120
Residue number B
121
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 120 of Tumor necrosis factor receptor superfamily member 9
Cysteine 121 of Tumor necrosis factor receptor superfamily member 9
6cu0 L 31 L 48
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 121 and 48 (31 and 48 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6cu0
Structure name
crystal structure of 4-1bbl/4-1bb (c121s) complex in p21 space group
Structure deposition date
2018-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
121
Residue number B
48
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 121 of Tumor necrosis factor receptor superfamily member 9
Cysteine 48 of Tumor necrosis factor receptor superfamily member 9
6mhr C 86 C 102
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 9 between cysteines 86 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6mhr
Structure name
structure of the human 4-1bb / urelumab fab complex
Structure deposition date
2018-09-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07011
Residue number A
86
Residue number B
102
Peptide name
Tumor necrosis factor receptor superfamily member 9
Ligandability
Cysteine 86 of Tumor necrosis factor receptor superfamily member 9
Cysteine 102 of Tumor necrosis factor receptor superfamily member 9
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