a tool for identifying drug-targetable redox-active disulphides

Glutamyl aminopeptidase

Intramolecular

Cysteine 78 and cysteine 160

A redox-regulated disulphide may form within Glutamyl aminopeptidase between cysteines 78 and 160.

Details

Redox score ?

87

PDB code

Structure name

crystal structure of human aminopeptidase a complexed with bestatin

Structure deposition date

2013-05-24

Thiol separation (Å)

3

Half-sphere exposure sum ?

62

Minimum pK_a ?

7

% buried

57

Peptide accession

Residue number A

78

Residue number B

160

Peptide name

Glutamyl aminopeptidase

Ligandability

Cysteine 78 of Glutamyl aminopeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Glutamyl aminopeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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