ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Early activation antigen CD69

Intermolecular
Cysteine 85 and cysteine 85
Intramolecular
Cysteine 85 and cysteine 96
Cysteine 173 and cysteine 186
Cysteine 113 and cysteine 194
A redox-regulated disulphide may form between two units of Early activation antigen CD69 at cysteines 85 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3cck
Structure name
human cd69
Structure deposition date
2008-02-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Early activation antigen CD69
Peptide B name
Early activation antigen CD69
Peptide A accession
Q07108
Peptide B accession
Q07108
Peptide A residue number
85
Peptide B residue number
85

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early activation antigen CD69 between cysteines 85 and 96.

Details

Redox score ?
86
PDB code
1e87
Structure name
human cd69 - trigonal form
Structure deposition date
2000-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07108
Residue number A
85
Residue number B
96
Peptide name
Early activation antigen CD69

Ligandability

Cysteine 85 of Early activation antigen CD69

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Early activation antigen CD69

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early activation antigen CD69 between cysteines 173 and 186.

Details

Redox score ?
84
PDB code
1e87
Structure name
human cd69 - trigonal form
Structure deposition date
2000-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07108
Residue number A
173
Residue number B
186
Peptide name
Early activation antigen CD69

Ligandability

Cysteine 173 of Early activation antigen CD69

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Early activation antigen CD69

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Early activation antigen CD69 between cysteines 113 and 194.

Details

Redox score ?
82
PDB code
1e8i
Structure name
human cd69 - tetragonal form
Structure deposition date
2000-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07108
Residue number A
113
Residue number B
194
Peptide name
Early activation antigen CD69

Ligandability

Cysteine 113 of Early activation antigen CD69

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Early activation antigen CD69

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: