ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tight junction protein ZO-1

Intramolecular
Cysteine 1718 and cysteine 1740
Cysteine 1676 and cysteine 1718
A redox-regulated disulphide may form within Tight junction protein ZO-1 between cysteines 1718 and 1740 (88 and 110 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2kxr
Structure name
zo1 zu5 domain mc/aa mutation
Structure deposition date
2010-05-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
39
Minimum pKa ?
9
% buried
8
Peptide accession
Q07157
Residue number A
1718
Residue number B
1740
Peptide name
Tight junction protein ZO-1

Ligandability

Cysteine 1718 of Tight junction protein ZO-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1740 of Tight junction protein ZO-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tight junction protein ZO-1 between cysteines 1676 and 1718 (46 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2kxr
Structure name
zo1 zu5 domain mc/aa mutation
Structure deposition date
2010-05-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
4
Peptide accession
Q07157
Residue number A
1676
Residue number B
1718
Peptide name
Tight junction protein ZO-1

Ligandability

Cysteine 1676 of Tight junction protein ZO-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1718 of Tight junction protein ZO-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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