a tool for identifying drug-targetable redox-active disulphides

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Intramolecular

Cysteine 604 and cysteine 671

A redox-regulated disulphide may form within cAMP-specific 3',5'-cyclic phosphodiesterase 4B between cysteines 604 and 671 (432 and 499 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

29

PDB code

Structure name

catalytic domain of human phosphodiesterase 4b2b

Structure deposition date

2000-05-16

Thiol separation (Å)

10

Half-sphere exposure sum ?

74

Minimum pK_a ?

13

% buried

88

Peptide accession

Residue number A

604

Residue number B

671

Peptide name

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Ligandability

Cysteine 604 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 671 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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