ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sperm-associated antigen 1

Intramolecular
Cysteine 633 and cysteine 666
Cysteine 633 and cysteine 649
A redox-regulated disulphide may form within Sperm-associated antigen 1 between cysteines 633 and 666. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6i57
Structure name
nmr structure of the third tpr domain of the human spag1 protein
Structure deposition date
2018-11-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
36
Peptide accession
Q07617
Residue number A
633
Residue number B
666
Peptide name
Sperm-associated antigen 1

Ligandability

Cysteine 633 of Sperm-associated antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 666 of Sperm-associated antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sperm-associated antigen 1 between cysteines 633 and 649. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6i57
Structure name
nmr structure of the third tpr domain of the human spag1 protein
Structure deposition date
2018-11-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
11
% buried
22
Peptide accession
Q07617
Residue number A
633
Residue number B
649
Peptide name
Sperm-associated antigen 1

Ligandability

Cysteine 633 of Sperm-associated antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 649 of Sperm-associated antigen 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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