Sodium channel subunit beta-1
Intermolecular
Cysteine 181 and cysteine 1199 of Sodium channel protein type 3 subunit alpha
Cysteine 1024 of Sodium channel protein type 4 subunit alpha and cysteine 181
Cysteine 1191 of Sodium channel protein type 8 subunit alpha and cysteine 181
Cysteine 1185 of Sodium channel protein type 9 subunit alpha and cysteine 181
Intramolecular
Cysteine 40 and cysteine 121
Cysteine 21 and cysteine 43
Cysteine 40 and cysteine 43
7w77 B 181 D 1199
A redox-regulated disulphide may form between cysteine 181 of Sodium channel subunit beta-1 and cysteine 1199 of Sodium channel protein type 3 subunit alpha. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7w77
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
40
Peptide A name
Sodium channel subunit beta-1
Peptide B name
Sodium channel protein type 3 subunit alpha
Peptide A accession
Q07699
Peptide B accession
Q9NY46
Peptide A residue number
181
Peptide B residue number
1199
Ligandability
Cysteine 181 of Sodium channel subunit beta-1
Cysteine 1199 of Sodium channel protein type 3 subunit alpha
6agf A 1024 B 181
A redox-regulated disulphide may form between cysteine 1024 of Sodium channel protein type 4 subunit alpha and cysteine 181 of Sodium channel subunit beta-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
32
Peptide A name
Sodium channel protein type 4 subunit alpha
Peptide B name
Sodium channel subunit beta-1
Peptide A accession
P35499
Peptide B accession
Q07699
Peptide A residue number
1024
Peptide B residue number
181
Ligandability
Cysteine 1024 of Sodium channel protein type 4 subunit alpha
Cysteine 181 of Sodium channel subunit beta-1
8fhd A 1191 C 181
A redox-regulated disulphide may form between cysteine 1191 of Sodium channel protein type 8 subunit alpha and cysteine 181 of Sodium channel subunit beta-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
8fhd
Structure name
cryo-em structure of human voltage-gated sodium channel nav1
Structure deposition date
2022-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
42
Peptide A name
Sodium channel protein type 8 subunit alpha
Peptide B name
Sodium channel subunit beta-1
Peptide A accession
Q9UQD0
Peptide B accession
Q07699
Peptide A residue number
1191
Peptide B residue number
181
Ligandability
Cysteine 1191 of Sodium channel protein type 8 subunit alpha
Cysteine 181 of Sodium channel subunit beta-1
7xve A 1185 B 181
A redox-regulated disulphide may form between cysteine 1185 of Sodium channel protein type 9 subunit alpha and cysteine 181 of Sodium channel subunit beta-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7xve
Structure name
human nav1
Structure deposition date
2022-05-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
51
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-1
Peptide A accession
Q15858
Peptide B accession
Q07699
Peptide A residue number
1185
Peptide B residue number
181
Ligandability
Cysteine 1185 of Sodium channel protein type 9 subunit alpha
Cysteine 181 of Sodium channel subunit beta-1
6agf B 40 B 121
A redox-regulated disulphide may form within Sodium channel subunit beta-1 between cysteines 40 and 121.
Details
Redox score ?
80
PDB code
6agf
Structure name
structure of the human voltage-gated sodium channel nav1
Structure deposition date
2018-08-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07699
Residue number A
40
Residue number B
121
Peptide name
Sodium channel subunit beta-1
Ligandability
Cysteine 40 of Sodium channel subunit beta-1
Cysteine 121 of Sodium channel subunit beta-1
7xmg B 21 B 43
A redox-regulated disulphide may form within Sodium channel subunit beta-1 between cysteines 21 and 43.
Details
Redox score ?
79
PDB code
7xmg
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
82
Peptide accession
Q07699
Residue number A
21
Residue number B
43
Peptide name
Sodium channel subunit beta-1
Ligandability
Cysteine 21 of Sodium channel subunit beta-1
Cysteine 43 of Sodium channel subunit beta-1
7w9l B 40 B 43
A redox-regulated disulphide may form within Sodium channel subunit beta-1 between cysteines 40 and 43. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7w9l
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07699
Residue number A
40
Residue number B
43
Peptide name
Sodium channel subunit beta-1
Ligandability
Cysteine 40 of Sodium channel subunit beta-1
Cysteine 43 of Sodium channel subunit beta-1
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