ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neutral and basic amino acid transport protein rBAT

Intermolecular
Cysteine 114 and cysteine 144 of b(0,+)-type amino acid transporter 1
Intramolecular
Cysteine 242 and cysteine 273
Cysteine 571 and cysteine 666
Cysteine 673 and cysteine 685
A redox-regulated disulphide may form between cysteine 114 of Neutral and basic amino acid transport protein rBAT and cysteine 144 of b(0,+)-type amino acid transporter 1.

Details

Redox score ?
80
PDB code
6yup
Structure name
heterotetrameric structure of the rbat-b(0,+)at1 complex
Structure deposition date
2020-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
52
Peptide A name
Neutral and basic amino acid transport protein rBAT
Peptide B name
b(0,+)-type amino acid transporter 1
Peptide A accession
Q07837
Peptide B accession
P82251
Peptide A residue number
114
Peptide B residue number
144

Ligandability

Cysteine 114 of Neutral and basic amino acid transport protein rBAT

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of b(0,+)-type amino acid transporter 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neutral and basic amino acid transport protein rBAT between cysteines 242 and 273.

Details

Redox score ?
86
PDB code
6lid
Structure name
heteromeric amino acid transporter b0,+at-rbat complex
Structure deposition date
2019-12-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07837
Residue number A
242
Residue number B
273
Peptide name
Neutral and basic amino acid transport protein rBAT

Ligandability

Cysteine 242 of Neutral and basic amino acid transport protein rBAT

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Neutral and basic amino acid transport protein rBAT

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neutral and basic amino acid transport protein rBAT between cysteines 571 and 666.

Details

Redox score ?
82
PDB code
6li9
Structure name
heteromeric amino acid transporter b0,+at-rbat complex bound with arginine
Structure deposition date
2019-12-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07837
Residue number A
571
Residue number B
666
Peptide name
Neutral and basic amino acid transport protein rBAT

Ligandability

Cysteine 571 of Neutral and basic amino acid transport protein rBAT

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 666 of Neutral and basic amino acid transport protein rBAT

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neutral and basic amino acid transport protein rBAT between cysteines 673 and 685.

Details

Redox score ?
81
PDB code
6li9
Structure name
heteromeric amino acid transporter b0,+at-rbat complex bound with arginine
Structure deposition date
2019-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
18
Peptide accession
Q07837
Residue number A
673
Residue number B
685
Peptide name
Neutral and basic amino acid transport protein rBAT

Ligandability

Cysteine 673 of Neutral and basic amino acid transport protein rBAT

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 685 of Neutral and basic amino acid transport protein rBAT

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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