DNA polymerase epsilon catalytic subunit A
Intramolecular
Cysteine 2236 and cysteine 2238
Cysteine 2158 and cysteine 2187
Cysteine 2221 and cysteine 2238
Cysteine 2224 and cysteine 2238
Cysteine 2221 and cysteine 2236
Cysteine 2158 and cysteine 2161
Cysteine 2161 and cysteine 2190
Cysteine 2158 and cysteine 2190
Cysteine 2161 and cysteine 2187
Cysteine 2224 and cysteine 2236
More...Cysteine 2187 and cysteine 2190
Cysteine 2221 and cysteine 2224
Cysteine 2164 and cysteine 2187
5vbn B 2236 B 2238
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2236 and 2238.
Details
Redox score ?
91
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
5
% buried
0
Peptide accession
Q07864
Residue number A
2236
Residue number B
2238
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2236 of DNA polymerase epsilon catalytic subunit A
Cysteine 2238 of DNA polymerase epsilon catalytic subunit A
5vbn F 2158 F 2187
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2158 and 2187.
Details
Redox score ?
91
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
0
Peptide accession
Q07864
Residue number A
2158
Residue number B
2187
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2158 of DNA polymerase epsilon catalytic subunit A
Cysteine 2187 of DNA polymerase epsilon catalytic subunit A
5vbn B 2221 B 2238
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2221 and 2238.
Details
Redox score ?
90
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
5
% buried
0
Peptide accession
Q07864
Residue number A
2221
Residue number B
2238
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2221 of DNA polymerase epsilon catalytic subunit A
Cysteine 2238 of DNA polymerase epsilon catalytic subunit A
5vbn F 2224 F 2238
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2224 and 2238.
Details
Redox score ?
88
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
0
Peptide accession
Q07864
Residue number A
2224
Residue number B
2238
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2224 of DNA polymerase epsilon catalytic subunit A
Cysteine 2238 of DNA polymerase epsilon catalytic subunit A
5vbn B 2221 B 2236
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2221 and 2236.
Details
Redox score ?
88
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
7
% buried
0
Peptide accession
Q07864
Residue number A
2221
Residue number B
2236
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2221 of DNA polymerase epsilon catalytic subunit A
Cysteine 2236 of DNA polymerase epsilon catalytic subunit A
5vbn F 2158 F 2161
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2158 and 2161.
Details
Redox score ?
87
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
0
Peptide accession
Q07864
Residue number A
2158
Residue number B
2161
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2158 of DNA polymerase epsilon catalytic subunit A
Cysteine 2161 of DNA polymerase epsilon catalytic subunit A
5vbn B 2161 B 2190
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2161 and 2190.
Details
Redox score ?
85
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
0
Peptide accession
Q07864
Residue number A
2161
Residue number B
2190
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2161 of DNA polymerase epsilon catalytic subunit A
Cysteine 2190 of DNA polymerase epsilon catalytic subunit A
5vbn B 2158 B 2190
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2158 and 2190.
Details
Redox score ?
85
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
7
% buried
0
Peptide accession
Q07864
Residue number A
2158
Residue number B
2190
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2158 of DNA polymerase epsilon catalytic subunit A
Cysteine 2190 of DNA polymerase epsilon catalytic subunit A
5vbn F 2161 F 2187
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2161 and 2187.
Details
Redox score ?
84
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
0
Peptide accession
Q07864
Residue number A
2161
Residue number B
2187
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2161 of DNA polymerase epsilon catalytic subunit A
Cysteine 2187 of DNA polymerase epsilon catalytic subunit A
5vbn F 2224 F 2236
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2224 and 2236.
Details
Redox score ?
83
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
0
Peptide accession
Q07864
Residue number A
2224
Residue number B
2236
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2224 of DNA polymerase epsilon catalytic subunit A
Cysteine 2236 of DNA polymerase epsilon catalytic subunit A
5vbn B 2187 B 2190
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2187 and 2190.
Details
Redox score ?
79
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
0
Peptide accession
Q07864
Residue number A
2187
Residue number B
2190
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2187 of DNA polymerase epsilon catalytic subunit A
Cysteine 2190 of DNA polymerase epsilon catalytic subunit A
5vbn B 2221 B 2224
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2221 and 2224.
Details
Redox score ?
79
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q07864
Residue number A
2221
Residue number B
2224
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2221 of DNA polymerase epsilon catalytic subunit A
Cysteine 2224 of DNA polymerase epsilon catalytic subunit A
5vbn B 2164 B 2187
A redox-regulated disulphide may form within DNA polymerase epsilon catalytic subunit A between cysteines 2164 and 2187. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
0
Peptide accession
Q07864
Residue number A
2164
Residue number B
2187
Peptide name
DNA polymerase epsilon catalytic subunit A
Ligandability
Cysteine 2164 of DNA polymerase epsilon catalytic subunit A
Cysteine 2187 of DNA polymerase epsilon catalytic subunit A
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