ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kinesin light chain 1

Intramolecular
Cysteine 320 and cysteine 349
Cysteine 349 and cysteine 390 L
A redox-regulated disulphide may form within Kinesin light chain 1 between cysteines 320 and 349. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7ai4
Structure name
crystal structure of the klc1-tpr domain truncated from its nontpr region ([a1-b6]-delta-nontpr fragment)
Structure deposition date
2020-09-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
48
Peptide accession
Q07866
Residue number A
320
Residue number B
349
Peptide name
Kinesin light chain 1

Ligandability

Cysteine 320 of Kinesin light chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Kinesin light chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin light chain 1 between cysteines 349 and 390. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7aie
Structure name
crystal structure of a truncated form of the klc1-tpr domain ([a1-b5] fragment) - monoclinic crystal form
Structure deposition date
2020-09-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
44
Peptide accession
Q07866
Residue number A
349
Residue number B
390
Peptide name
Kinesin light chain 1

Ligandability

Cysteine 349 of Kinesin light chain 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Kinesin light chain 1

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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