ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Son of sevenless homolog 1

Intramolecular
Cysteine 440 and cysteine 441
Cysteine 470 and cysteine 471
Cysteine 167 and cysteine 440
Cysteine 167 and cysteine 441
Cysteine 350 and cysteine 391
Cysteine 282 and cysteine 372
A redox-regulated disulphide may form within Son of sevenless homolog 1 between cysteines 440 and 441.

Details

Redox score ?
78
PDB code
1xdv
Structure name
experimentally phased structure of human the son of sevenless protein at 4
Structure deposition date
2004-09-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
33
Peptide accession
Q07889
Residue number A
440
Residue number B
441
Peptide name
Son of sevenless homolog 1

Ligandability

Cysteine 440 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Son of sevenless homolog 1 between cysteines 470 and 471 (487 and 488 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1pms
Structure name
pleckstrin homology domain of son of sevenless 1 (sos1) with glycine- serine added to the n-terminus, nmr, 20 structures
Structure deposition date
1997-02-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
58
Peptide accession
Q62245
Residue number A
470
Residue number B
471
Peptide name
Son of sevenless homolog 1

Ligandability

Cysteine 470 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Son of sevenless homolog 1 between cysteines 167 and 440. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3ksy
Structure name
crystal structure of the histone domain, dh-ph unit, and catalytic unit of the ras activator son of sevenless (sos)
Structure deposition date
2009-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
38
Peptide accession
Q07889
Residue number A
167
Residue number B
440
Peptide name
Son of sevenless homolog 1

Ligandability

Cysteine 167 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 440 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Son of sevenless homolog 1 between cysteines 167 and 441. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3ksy
Structure name
crystal structure of the histone domain, dh-ph unit, and catalytic unit of the ras activator son of sevenless (sos)
Structure deposition date
2009-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
47
Peptide accession
Q07889
Residue number A
167
Residue number B
441
Peptide name
Son of sevenless homolog 1

Ligandability

Cysteine 167 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Son of sevenless homolog 1 between cysteines 350 and 391. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3ksy
Structure name
crystal structure of the histone domain, dh-ph unit, and catalytic unit of the ras activator son of sevenless (sos)
Structure deposition date
2009-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
73
Peptide accession
Q07889
Residue number A
350
Residue number B
391
Peptide name
Son of sevenless homolog 1

Ligandability

Cysteine 350 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 391 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Son of sevenless homolog 1 between cysteines 282 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3ksy
Structure name
crystal structure of the histone domain, dh-ph unit, and catalytic unit of the ras activator son of sevenless (sos)
Structure deposition date
2009-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
64
Peptide accession
Q07889
Residue number A
282
Residue number B
372
Peptide name
Son of sevenless homolog 1

Ligandability

Cysteine 282 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of Son of sevenless homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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