ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Activated CDC42 kinase 1

Intermolecular
Cysteine 119 and cysteine 119
A redox-regulated disulphide may form between two units of Activated CDC42 kinase 1 at cysteines 119 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5zxb
Structure name
crystal structure of ack1 with compound 10d
Structure deposition date
2018-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
65
Peptide A name
Activated CDC42 kinase 1
Peptide B name
Activated CDC42 kinase 1
Peptide A accession
Q07912
Peptide B accession
Q07912
Peptide A residue number
119
Peptide B residue number
119

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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