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a tool for identifying drug-targetable redox-active disulphides

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Prolow-density lipoprotein receptor-related protein 1

Intramolecular
Cysteine 1069 and cysteine 1088
Cysteine 2781 and cysteine 2800
Cysteine 861 and cysteine 879
Cysteine 1022 and cysteine 1040
Cysteine 2794 and cysteine 2812
Cysteine 1034 and cysteine 1051
Cysteine 1082 and cysteine 1097
Cysteine 936 and cysteine 948
Cysteine 1015 and cysteine 1027
Cysteine 984 and cysteine 1002
More...
Cysteine 1062 and cysteine 1075
Cysteine 854 and cysteine 866
Cysteine 2774 and cysteine 2787
Cysteine 873 and cysteine 890
Cysteine 976 and cysteine 989
Cysteine 943 and cysteine 961
Cysteine 955 and cysteine 971
Cysteine 996 and cysteine 1011
Cysteine 1015 and cysteine 1022
Cysteine 1022 and cysteine 1027
Cysteine 2781 and cysteine 2787
Cysteine 2774 and cysteine 2800
Cysteine 2800 and cysteine 2812
Cysteine 1015 and cysteine 1040
Cysteine 936 and cysteine 943
Cysteine 971 and cysteine 976
Cysteine 2787 and cysteine 2800
Cysteine 976 and cysteine 984
Cysteine 2774 and cysteine 2781
Cysteine 1062 and cysteine 1069
Cysteine 943 and cysteine 971
Cysteine 1062 and cysteine 1088
Cysteine 1027 and cysteine 1040
Cysteine 971 and cysteine 989
Cysteine 936 and cysteine 961
Cysteine 984 and cysteine 989
Cysteine 1069 and cysteine 1075
Cysteine 2794 and cysteine 2800
Cysteine 989 and cysteine 1002
Cysteine 943 and cysteine 948
A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1069 and 1088 (13 and 32 respectively in this structure).

Details

Redox score ?
89
PDB code
1cr8
Structure name
low density lipoprotein receptor-related protein complement repeat 8
Structure deposition date
1998-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1069
Residue number B
1088
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1069 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1088 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2781 and 2800 (14 and 33 respectively in this structure).

Details

Redox score ?
88
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2781
Residue number B
2800
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2781 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2800 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 861 and 879 (13 and 31 respectively in this structure).

Details

Redox score ?
88
PDB code
1d2l
Structure name
nmr solution structure of complement-like repeat cr3 from the low density lipoprotein receptor-related protein (lrp)
Structure deposition date
1999-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
861
Residue number B
879
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 861 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 879 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1022 and 1040 (12 and 30 respectively in this structure).

Details

Redox score ?
88
PDB code
1j8e
Structure name
crystal structure of ligand-binding repeat cr7 from lrp
Structure deposition date
2001-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1022
Residue number B
1040
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1022 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1040 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2794 and 2812 (27 and 45 respectively in this structure).

Details

Redox score ?
87
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2794
Residue number B
2812
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2794 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2812 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1034 and 1051 (24 and 41 respectively in this structure).

Details

Redox score ?
87
PDB code
1j8e
Structure name
crystal structure of ligand-binding repeat cr7 from lrp
Structure deposition date
2001-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1034
Residue number B
1051
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1034 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1051 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1082 and 1097 (26 and 41 respectively in this structure).

Details

Redox score ?
87
PDB code
1cr8
Structure name
low density lipoprotein receptor-related protein complement repeat 8
Structure deposition date
1998-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1082
Residue number B
1097
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1082 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1097 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 936 and 948 (5 and 17 respectively in this structure).

Details

Redox score ?
86
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
936
Residue number B
948
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 936 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 948 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1015 and 1027 (5 and 17 respectively in this structure).

Details

Redox score ?
86
PDB code
1j8e
Structure name
crystal structure of ligand-binding repeat cr7 from lrp
Structure deposition date
2001-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1015
Residue number B
1027
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1015 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1027 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 984 and 1002 (53 and 71 respectively in this structure).

Details

Redox score ?
85
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
984
Residue number B
1002
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 984 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1002 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1062 and 1075 (6 and 19 respectively in this structure).

Details

Redox score ?
85
PDB code
1cr8
Structure name
low density lipoprotein receptor-related protein complement repeat 8
Structure deposition date
1998-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1062
Residue number B
1075
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1062 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1075 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 854 and 866 (6 and 18 respectively in this structure).

Details

Redox score ?
85
PDB code
1d2l
Structure name
nmr solution structure of complement-like repeat cr3 from the low density lipoprotein receptor-related protein (lrp)
Structure deposition date
1999-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
854
Residue number B
866
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 854 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 866 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2774 and 2787 (7 and 20 respectively in this structure).

Details

Redox score ?
84
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2774
Residue number B
2787
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2774 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2787 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 873 and 890 (25 and 42 respectively in this structure).

Details

Redox score ?
84
PDB code
1d2l
Structure name
nmr solution structure of complement-like repeat cr3 from the low density lipoprotein receptor-related protein (lrp)
Structure deposition date
1999-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
873
Residue number B
890
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 873 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 890 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 976 and 989 (45 and 58 respectively in this structure).

Details

Redox score ?
84
PDB code
2fyl
Structure name
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1
Structure deposition date
2006-02-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
976
Residue number B
989
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 976 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 989 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 943 and 961 (12 and 30 respectively in this structure).

Details

Redox score ?
83
PDB code
2fyl
Structure name
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1
Structure deposition date
2006-02-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
943
Residue number B
961
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 943 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 961 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 955 and 971 (24 and 40 respectively in this structure).

Details

Redox score ?
83
PDB code
2fyl
Structure name
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1
Structure deposition date
2006-02-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
955
Residue number B
971
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 955 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 971 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 996 and 1011 (65 and 80 respectively in this structure).

Details

Redox score ?
76
PDB code
2fyl
Structure name
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1
Structure deposition date
2006-02-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q07954
Residue number A
996
Residue number B
1011
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 996 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1011 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1015 and 1022 (5 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1j8e
Structure name
crystal structure of ligand-binding repeat cr7 from lrp
Structure deposition date
2001-05-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1015
Residue number B
1022
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1015 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1022 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1022 and 1027 (12 and 17 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1j8e
Structure name
crystal structure of ligand-binding repeat cr7 from lrp
Structure deposition date
2001-05-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1022
Residue number B
1027
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1022 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1027 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2781 and 2787 (14 and 20 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2781
Residue number B
2787
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2781 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2787 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2774 and 2800 (7 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2774
Residue number B
2800
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2774 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2800 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2800 and 2812 (33 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2800
Residue number B
2812
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2800 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2812 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1015 and 1040 (5 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1j8e
Structure name
crystal structure of ligand-binding repeat cr7 from lrp
Structure deposition date
2001-05-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1015
Residue number B
1040
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1015 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1040 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 936 and 943 (5 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
936
Residue number B
943
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 936 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 943 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 971 and 976 (40 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2fyl
Structure name
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1
Structure deposition date
2006-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
971
Residue number B
976
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 971 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 976 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2787 and 2800 (20 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2787
Residue number B
2800
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2787 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2800 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 976 and 984 (45 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
976
Residue number B
984
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 976 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 984 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2774 and 2781 (7 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2774
Residue number B
2781
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2774 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2781 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1062 and 1069 (6 and 13 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1cr8
Structure name
low density lipoprotein receptor-related protein complement repeat 8
Structure deposition date
1998-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1062
Residue number B
1069
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1062 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1069 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 943 and 971 (12 and 40 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
943
Residue number B
971
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 943 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 971 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1062 and 1088 (6 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1cr8
Structure name
low density lipoprotein receptor-related protein complement repeat 8
Structure deposition date
1998-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1062
Residue number B
1088
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1062 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1088 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1027 and 1040 (17 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1j8e
Structure name
crystal structure of ligand-binding repeat cr7 from lrp
Structure deposition date
2001-05-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1027
Residue number B
1040
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1027 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1040 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 971 and 989 (40 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
971
Residue number B
989
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 971 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 989 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 936 and 961 (5 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
936
Residue number B
961
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 936 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 961 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 984 and 989 (53 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2fyl
Structure name
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1
Structure deposition date
2006-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
984
Residue number B
989
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 984 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 989 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 1069 and 1075 (13 and 19 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1cr8
Structure name
low density lipoprotein receptor-related protein complement repeat 8
Structure deposition date
1998-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
1069
Residue number B
1075
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 1069 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1075 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 2794 and 2800 (27 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2knx
Structure name
solution structure of complement repeat cr17 from lrp-1
Structure deposition date
2009-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
2794
Residue number B
2800
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 2794 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2800 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 989 and 1002 (58 and 71 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
989
Residue number B
1002
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 989 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1002 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Prolow-density lipoprotein receptor-related protein 1 between cysteines 943 and 948 (12 and 17 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2fyj
Structure name
nmr solution structure of calcium-loaded lrp double module
Structure deposition date
2006-02-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q07954
Residue number A
943
Residue number B
948
Peptide name
Prolow-density lipoprotein receptor-related protein 1

Ligandability

Cysteine 943 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 948 of Prolow-density lipoprotein receptor-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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