a tool for identifying drug-targetable redox-active disulphides

Regulator of G-protein signaling 1

Intramolecular

Cysteine 118 and cysteine 170

A redox-regulated disulphide may form within Regulator of G-protein signaling 1 between cysteines 118 and 170 (105 and 157 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

crystal structure of the heterodimeric complex of human rgs1 and activated gi alpha 1

Structure deposition date

2006-04-28

Thiol separation (Å)

9

Half-sphere exposure sum ?

67

Minimum pK_a ?

11

% buried

62

Peptide accession

Residue number A

118

Residue number B

170

Peptide name

Regulator of G-protein signaling 1

Ligandability

Cysteine 118 of Regulator of G-protein signaling 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Regulator of G-protein signaling 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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