ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-10 receptor subunit beta

Intramolecular
Cysteine 66 and cysteine 74
Cysteine 188 and cysteine 209
A redox-regulated disulphide may form within Interleukin-10 receptor subunit beta between cysteines 66 and 74.

Details

Redox score ?
83
PDB code
5t5w
Structure name
structure of an affinity matured lambda-ifn/ifn-lambdar1/il-10rbeta receptor complex
Structure deposition date
2016-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q08334
Residue number A
66
Residue number B
74
Peptide name
Interleukin-10 receptor subunit beta

Ligandability

Cysteine 66 of Interleukin-10 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Interleukin-10 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-10 receptor subunit beta between cysteines 188 and 209.

Details

Redox score ?
81
PDB code
3lqm
Structure name
structure of the il-10r2 common chain
Structure deposition date
2010-02-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q08334
Residue number A
188
Residue number B
209
Peptide name
Interleukin-10 receptor subunit beta

Ligandability

Cysteine 188 of Interleukin-10 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Interleukin-10 receptor subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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