a tool for identifying drug-targetable redox-active disulphides

Lactadherin

Intramolecular

Cysteine 308 and cysteine 463

A redox-regulated disulphide may form within Lactadherin between cysteines 308 and 463 (1 and 156 respectively in this structure).

Details

Redox score ?

85

PDB code

Structure name

nmr structure of the mouse mfg-e8 c2 domain

Structure deposition date

2011-02-21

Thiol separation (Å)

2

Half-sphere exposure sum ?

45

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

308

Residue number B

463

Peptide name

Lactadherin

Ligandability

Cysteine 308 of Lactadherin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 463 of Lactadherin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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