ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adenylate cyclase type 2

Intermolecular
Cysteine 911 and cysteine 237 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Intramolecular
Cysteine 1056 and cysteine 1058
Cysteine 884 and cysteine 886
A redox-regulated disulphide may form between cysteine 911 of Adenylate cyclase type 2 and cysteine 237 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
2gvz
Structure name
crystal structure of complex of gs- with the catalytic domains of mammalian adenylyl cyclase: complex with mant-atp and mn
Structure deposition date
2006-05-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
100
Peptide A name
Adenylate cyclase type 2
Peptide B name
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Peptide A accession
P26769
Peptide B accession
P04896
Peptide A residue number
911
Peptide B residue number
237

Ligandability

Cysteine 911 of Adenylate cyclase type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylate cyclase type 2 between cysteines 1056 and 1058. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1cs4
Structure name
complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with 2'-deoxy-adenosine 3'-monophosphate, pyrophosphate and mg
Structure deposition date
1999-08-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
20
Peptide accession
P26769
Residue number A
1056
Residue number B
1058
Peptide name
Adenylate cyclase type 2

Ligandability

Cysteine 1056 of Adenylate cyclase type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1058 of Adenylate cyclase type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylate cyclase type 2 between cysteines 884 and 886. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1cjk
Structure name
complex of gs-alpha with the catalytic domains of mammalian adenylyl cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp), mg, and mn
Structure deposition date
1999-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
62
Peptide accession
P26769
Residue number A
884
Residue number B
886
Peptide name
Adenylate cyclase type 2

Ligandability

Cysteine 884 of Adenylate cyclase type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 886 of Adenylate cyclase type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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