ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leukocyte surface antigen CD47

Intramolecular
Cysteine 33 and cysteine 263
Cysteine 41 and cysteine 114
A redox-regulated disulphide may form within Leukocyte surface antigen CD47 between cysteines 33 and 263 (15 and 245 respectively in this structure).

Details

Redox score ?
85
PDB code
7myz
Structure name
structure of the full length 5-tm receptor cd47 bound to fab b6h12
Structure deposition date
2021-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q08722
Residue number A
33
Residue number B
263
Peptide name
Leukocyte surface antigen CD47

Ligandability

Cysteine 33 of Leukocyte surface antigen CD47

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of Leukocyte surface antigen CD47

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte surface antigen CD47 between cysteines 41 and 114 (23 and 96 respectively in this structure).

Details

Redox score ?
80
PDB code
4kjy
Structure name
complex of high-affinity sirp alpha variant fd6 with cd47
Structure deposition date
2013-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q08722
Residue number A
41
Residue number B
114
Peptide name
Leukocyte surface antigen CD47

Ligandability

Cysteine 41 of Leukocyte surface antigen CD47

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Leukocyte surface antigen CD47

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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