ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peptidyl-prolyl cis-trans isomerase D

Intramolecular
Cysteine 52 and cysteine 181
Cysteine 71 and cysteine 181
A redox-regulated disulphide may form within Peptidyl-prolyl cis-trans isomerase D between cysteines 52 and 181. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
1ihg
Structure name
bovine cyclophilin 40, monoclinic form
Structure deposition date
2001-04-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
86
Peptide accession
P26882
Residue number A
52
Residue number B
181
Peptide name
Peptidyl-prolyl cis-trans isomerase D

Ligandability

Cysteine 52 of Peptidyl-prolyl cis-trans isomerase D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Peptidyl-prolyl cis-trans isomerase D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidyl-prolyl cis-trans isomerase D between cysteines 71 and 181. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1iip
Structure name
bovine cyclophilin 40, tetragonal form
Structure deposition date
2001-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
82
Peptide accession
P26882
Residue number A
71
Residue number B
181
Peptide name
Peptidyl-prolyl cis-trans isomerase D

Ligandability

Cysteine 71 of Peptidyl-prolyl cis-trans isomerase D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 181 of Peptidyl-prolyl cis-trans isomerase D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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