Schlafen family member 5
Intramolecular
Cysteine 268 and cysteine 303
Cysteine 268 and cysteine 302
Cysteine 302 and cysteine 303
Cysteine 342 and cysteine 362 L
Cysteine 610 and cysteine 627 L
Cysteine 207 and cysteine 241
Cysteine 139 and cysteine 303
Cysteine 463 and cysteine 495
Cysteine 207 and cysteine 215
Cysteine 439 and cysteine 495
More...Cysteine 241 and cysteine 294
Cysteine 207 and cysteine 294
Cysteine 48 and cysteine 114 L
Cysteine 215 and cysteine 258
7cux C 268 C 303
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 268 and 303.
Details
Redox score ?
85
PDB code
7cux
Structure name
crystal structure of human schlafen 5 n'-terminal domain (slfn5-n) involved in ssrna cleaving and dna binding
Structure deposition date
2020-08-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
12
Peptide accession
Q08AF3
Residue number A
268
Residue number B
303
Peptide name
Schlafen family member 5
Ligandability
Cysteine 268 of Schlafen family member 5
Cysteine 303 of Schlafen family member 5
7cux E 268 E 302
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 268 and 302.
Details
Redox score ?
81
PDB code
7cux
Structure name
crystal structure of human schlafen 5 n'-terminal domain (slfn5-n) involved in ssrna cleaving and dna binding
Structure deposition date
2020-08-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
Q08AF3
Residue number A
268
Residue number B
302
Peptide name
Schlafen family member 5
Ligandability
Cysteine 268 of Schlafen family member 5
Cysteine 302 of Schlafen family member 5
7cux D 302 D 303
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 302 and 303.
Details
Redox score ?
71
PDB code
7cux
Structure name
crystal structure of human schlafen 5 n'-terminal domain (slfn5-n) involved in ssrna cleaving and dna binding
Structure deposition date
2020-08-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
14
Peptide accession
Q08AF3
Residue number A
302
Residue number B
303
Peptide name
Schlafen family member 5
Ligandability
Cysteine 302 of Schlafen family member 5
Cysteine 303 of Schlafen family member 5
7ppj A 342 A 362
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 342 and 362. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7ppj
Structure name
human slfn5
Structure deposition date
2021-09-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
24
Peptide accession
Q08AF3
Residue number A
342
Residue number B
362
Peptide name
Schlafen family member 5
Ligandability
Cysteine 342 of Schlafen family member 5
Cysteine 362 of Schlafen family member 5
7ppj A 610 A 627
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 610 and 627. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7ppj
Structure name
human slfn5
Structure deposition date
2021-09-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
69
Peptide accession
Q08AF3
Residue number A
610
Residue number B
627
Peptide name
Schlafen family member 5
Ligandability
Cysteine 610 of Schlafen family member 5
Cysteine 627 of Schlafen family member 5
7q3z B 207 B 241
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 207 and 241. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7q3z
Structure name
dna/rna binding protein
Structure deposition date
2021-10-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
52
Peptide accession
Q08AF3
Residue number A
207
Residue number B
241
Peptide name
Schlafen family member 5
Ligandability
Cysteine 207 of Schlafen family member 5
Cysteine 241 of Schlafen family member 5
7cux A 139 A 303
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 139 and 303. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7cux
Structure name
crystal structure of human schlafen 5 n'-terminal domain (slfn5-n) involved in ssrna cleaving and dna binding
Structure deposition date
2020-08-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
21
Peptide accession
Q08AF3
Residue number A
139
Residue number B
303
Peptide name
Schlafen family member 5
Ligandability
Cysteine 139 of Schlafen family member 5
Cysteine 303 of Schlafen family member 5
7ppj A 463 A 495
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 463 and 495. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7ppj
Structure name
human slfn5
Structure deposition date
2021-09-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
36
Peptide accession
Q08AF3
Residue number A
463
Residue number B
495
Peptide name
Schlafen family member 5
Ligandability
Cysteine 463 of Schlafen family member 5
Cysteine 495 of Schlafen family member 5
7q3z B 207 B 215
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 207 and 215. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7q3z
Structure name
dna/rna binding protein
Structure deposition date
2021-10-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
72
Peptide accession
Q08AF3
Residue number A
207
Residue number B
215
Peptide name
Schlafen family member 5
Ligandability
Cysteine 207 of Schlafen family member 5
Cysteine 215 of Schlafen family member 5
7ppj A 439 A 495
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 439 and 495. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7ppj
Structure name
human slfn5
Structure deposition date
2021-09-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
85
Peptide accession
Q08AF3
Residue number A
439
Residue number B
495
Peptide name
Schlafen family member 5
Ligandability
Cysteine 439 of Schlafen family member 5
Cysteine 495 of Schlafen family member 5
6rr9 A 241 A 294
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 241 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6rr9
Structure name
dna/rna binding protein
Structure deposition date
2019-05-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
78
Peptide accession
Q08AF3
Residue number A
241
Residue number B
294
Peptide name
Schlafen family member 5
Ligandability
Cysteine 241 of Schlafen family member 5
Cysteine 294 of Schlafen family member 5
7cux A 207 A 294
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 207 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7cux
Structure name
crystal structure of human schlafen 5 n'-terminal domain (slfn5-n) involved in ssrna cleaving and dna binding
Structure deposition date
2020-08-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
76
Peptide accession
Q08AF3
Residue number A
207
Residue number B
294
Peptide name
Schlafen family member 5
Ligandability
Cysteine 207 of Schlafen family member 5
Cysteine 294 of Schlafen family member 5
7ppj A 48 A 114
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 48 and 114. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7ppj
Structure name
human slfn5
Structure deposition date
2021-09-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
84
Peptide accession
Q08AF3
Residue number A
48
Residue number B
114
Peptide name
Schlafen family member 5
Ligandability
Cysteine 48 of Schlafen family member 5
Cysteine 114 of Schlafen family member 5
7q3z B 215 B 258
A redox-regulated disulphide may form within Schlafen family member 5 between cysteines 215 and 258. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
7q3z
Structure name
dna/rna binding protein
Structure deposition date
2021-10-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
95
Peptide accession
Q08AF3
Residue number A
215
Residue number B
258
Peptide name
Schlafen family member 5
Ligandability
Cysteine 215 of Schlafen family member 5
Cysteine 258 of Schlafen family member 5
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