ATP-binding cassette sub-family C member 8
Intramolecular
Cysteine 6 and cysteine 26
Cysteine 677 and cysteine 678
Cysteine 292 and cysteine 435
Cysteine 87 and cysteine 170
Cysteine 1149 and cysteine 1174
Cysteine 1071 and cysteine 1078
Cysteine 87 and cysteine 1257
Cysteine 1175 and cysteine 1251
Cysteine 1174 and cysteine 1257
7s5x E 7 E 27
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 6 and 26 (7 and 27 respectively in this structure).
Details
Redox score ?
69
PDB code
7s5x
Structure name
human katp channel in open conformation, focused on kir and one sur, position 1
Structure deposition date
2021-09-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
92
Peptide accession
Q09428
Residue number A
6
Residue number B
26
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 6 of ATP-binding cassette sub-family C member 8
Cysteine 26 of ATP-binding cassette sub-family C member 8
7s5v E 678 E 679
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 677 and 678 (678 and 679 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
7s5v
Structure name
human katp channel in open conformation, focused on sur
Structure deposition date
2021-09-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
36
Peptide accession
Q09428
Residue number A
677
Residue number B
678
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 677 of ATP-binding cassette sub-family C member 8
Cysteine 678 of ATP-binding cassette sub-family C member 8
7u1q E 292 E 435
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 292 and 435. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7u1q
Structure name
cryo-em structure of the pancreatic atp-sensitive potassium channel bound to atp and repaglinide with sur1-in conformation
Structure deposition date
2022-02-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
58
Peptide accession
Q09427
Residue number A
292
Residue number B
435
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 292 of ATP-binding cassette sub-family C member 8
Cysteine 435 of ATP-binding cassette sub-family C member 8
7s5y E 88 E 171
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 87 and 170 (88 and 171 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7s5y
Structure name
human katp channel in open conformation, focused on kir and one sur, position 2
Structure deposition date
2021-09-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
34
Peptide accession
Q09428
Residue number A
87
Residue number B
170
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 87 of ATP-binding cassette sub-family C member 8
Cysteine 170 of ATP-binding cassette sub-family C member 8
7s5v E 1150 E 1175
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 1149 and 1174 (1150 and 1175 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7s5v
Structure name
human katp channel in open conformation, focused on sur
Structure deposition date
2021-09-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
74
Peptide accession
Q09428
Residue number A
1149
Residue number B
1174
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 1149 of ATP-binding cassette sub-family C member 8
Cysteine 1174 of ATP-binding cassette sub-family C member 8
7s5y E 1072 E 1079
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 1071 and 1078 (1072 and 1079 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7s5y
Structure name
human katp channel in open conformation, focused on kir and one sur, position 2
Structure deposition date
2021-09-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
64
Peptide accession
Q09428
Residue number A
1071
Residue number B
1078
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 1071 of ATP-binding cassette sub-family C member 8
Cysteine 1078 of ATP-binding cassette sub-family C member 8
6c3o F 87 F 1257
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 87 and 1257. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6c3o
Structure name
cryo-em structure of human katp bound to atp and adp in quatrefoil form
Structure deposition date
2018-01-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
45
Peptide accession
Q09428
Residue number A
87
Residue number B
1257
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 87 of ATP-binding cassette sub-family C member 8
Cysteine 1257 of ATP-binding cassette sub-family C member 8
6baa H 1175 H 1251
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 1175 and 1251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
6baa
Structure name
cryo-em structure of the pancreatic beta-cell katp channel bound to atp and glibenclamide
Structure deposition date
2017-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
74
Peptide accession
Q09427
Residue number A
1175
Residue number B
1251
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 1175 of ATP-binding cassette sub-family C member 8
Cysteine 1251 of ATP-binding cassette sub-family C member 8
7s5v E 1175 E 1258
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 between cysteines 1174 and 1257 (1175 and 1258 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7s5v
Structure name
human katp channel in open conformation, focused on sur
Structure deposition date
2021-09-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
54
Peptide accession
Q09428
Residue number A
1174
Residue number B
1257
Peptide name
ATP-binding cassette sub-family C member 8
Ligandability
Cysteine 1174 of ATP-binding cassette sub-family C member 8
Cysteine 1257 of ATP-binding cassette sub-family C member 8
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