ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Immunoblobulin light chain

Intramolecular
Cysteine 23 and cysteine 93
Cysteine 139 and cysteine 199
A redox-regulated disulphide may form within Immunoblobulin light chain between cysteines 23 and 93 (23 and 96 respectively in this structure).

Details

Redox score ?
80
PDB code
5w1m
Structure name
macv gp1 cr1-07 fab complex
Structure deposition date
2017-06-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q0KKI6
Residue number A
23
Residue number B
93
Peptide name
Immunoblobulin light chain

Ligandability

Cysteine 23 of Immunoblobulin light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Immunoblobulin light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoblobulin light chain between cysteines 139 and 199 (134 and 194 respectively in this structure).

Details

Redox score ?
78
PDB code
5vzy
Structure name
crystal structure of crenezumab fab in complex with abeta
Structure deposition date
2017-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q0KKI6
Residue number A
139
Residue number B
199
Peptide name
Immunoblobulin light chain

Ligandability

Cysteine 139 of Immunoblobulin light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Immunoblobulin light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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