ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-13

Intramolecular
Cysteine 48 and cysteine 76
Cysteine 64 and cysteine 90
A redox-regulated disulphide may form within Interleukin-13 between cysteines 48 and 76 (29 and 57 respectively in this structure).

Details

Redox score ?
88
PDB code
7rew
Structure name
crystal structure of il-13 in complex with mmab3 fab
Structure deposition date
2021-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q0PW92
Residue number A
48
Residue number B
76
Peptide name
Interleukin-13

Ligandability

Cysteine 48 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-13 between cysteines 64 and 90 (45 and 71 respectively in this structure).

Details

Redox score ?
83
PDB code
7rew
Structure name
crystal structure of il-13 in complex with mmab3 fab
Structure deposition date
2021-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q0PW92
Residue number A
64
Residue number B
90
Peptide name
Interleukin-13

Ligandability

Cysteine 64 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Interleukin-13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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