ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Intramolecular
Cysteine 378 and cysteine 386
Cysteine 196 and cysteine 210
Cysteine 283 and cysteine 286
Cysteine 334 and cysteine 357
Cysteine 339 and cysteine 440
A redox-regulated disulphide may form within Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase between cysteines 378 and 386.

Details

Redox score ?
91
PDB code
5vcm
Structure name
alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase with bound udp and manganese
Structure deposition date
2017-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10469
Residue number A
378
Residue number B
386
Peptide name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Ligandability

Cysteine 378 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 386 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase between cysteines 196 and 210.

Details

Redox score ?
88
PDB code
5vcs
Structure name
alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase with bound acceptor
Structure deposition date
2017-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10469
Residue number A
196
Residue number B
210
Peptide name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Ligandability

Cysteine 196 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase between cysteines 283 and 286.

Details

Redox score ?
88
PDB code
5vcs
Structure name
alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase with bound acceptor
Structure deposition date
2017-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10469
Residue number A
283
Residue number B
286
Peptide name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Ligandability

Cysteine 283 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase between cysteines 334 and 357.

Details

Redox score ?
85
PDB code
5vcs
Structure name
alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase with bound acceptor
Structure deposition date
2017-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10469
Residue number A
334
Residue number B
357
Peptide name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Ligandability

Cysteine 334 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase between cysteines 339 and 440.

Details

Redox score ?
82
PDB code
5vcs
Structure name
alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase with bound acceptor
Structure deposition date
2017-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10469
Residue number A
339
Residue number B
440
Peptide name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Ligandability

Cysteine 339 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 440 of Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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