ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cleavage and polyadenylation specificity factor subunit 1

Intramolecular
Cysteine 1126 and cysteine 1135
Cysteine 238 and cysteine 265
Cysteine 1176 and cysteine 1178
Cysteine 1102 and cysteine 1126
Cysteine 699 and cysteine 785
Cysteine 503 and cysteine 1020
Cysteine 475 and cysteine 503
Cysteine 1102 and cysteine 1176
A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 1126 and 1135.

Details

Redox score ?
65
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
100
Peptide accession
Q10570
Residue number A
1126
Residue number B
1135
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 1126 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1135 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 238 and 265.

Details

Redox score ?
64
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
100
Peptide accession
Q10570
Residue number A
238
Residue number B
265
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 238 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 265 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 1176 and 1178. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
83
Peptide accession
Q10570
Residue number A
1176
Residue number B
1178
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 1176 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1178 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 1102 and 1126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
Q10570
Residue number A
1102
Residue number B
1126
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 1102 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1126 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 699 and 785. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide accession
Q10570
Residue number A
699
Residue number B
785
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 699 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 785 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 503 and 1020. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
82
Peptide accession
Q10570
Residue number A
503
Residue number B
1020
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 503 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1020 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 475 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
101
Minimum pKa ?
13
% buried
100
Peptide accession
Q10570
Residue number A
475
Residue number B
503
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 475 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cleavage and polyadenylation specificity factor subunit 1 between cysteines 1102 and 1176. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
6f9n
Structure name
crystal structure of the human cpsf160-wdr33 complex
Structure deposition date
2017-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
Q10570
Residue number A
1102
Residue number B
1176
Peptide name
Cleavage and polyadenylation specificity factor subunit 1

Ligandability

Cysteine 1102 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1176 of Cleavage and polyadenylation specificity factor subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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