ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Bone marrow stromal antigen 2

Intermolecular
Cysteine 91 and cysteine 91
Cysteine 63 and cysteine 63
Cysteine 53 and cysteine 53
A redox-regulated disulphide may form between two units of Bone marrow stromal antigen 2 at cysteines 91 and 91.

Details

Redox score ?
75
PDB code
3nwh
Structure name
crystal structure of bst2/tetherin
Structure deposition date
2010-07-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
7
Peptide A name
Bone marrow stromal antigen 2
Peptide B name
Bone marrow stromal antigen 2
Peptide A accession
Q10589
Peptide B accession
Q10589
Peptide A residue number
91
Peptide B residue number
91

Ligandability

A redox-regulated disulphide may form between two units of Bone marrow stromal antigen 2 at cysteines 63 and 63. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3nwh
Structure name
crystal structure of bst2/tetherin
Structure deposition date
2010-07-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
82
Peptide A name
Bone marrow stromal antigen 2
Peptide B name
Bone marrow stromal antigen 2
Peptide A accession
Q10589
Peptide B accession
Q10589
Peptide A residue number
63
Peptide B residue number
63

Ligandability

A redox-regulated disulphide may form between two units of Bone marrow stromal antigen 2 at cysteines 53 and 53. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3mqb
Structure name
crystal structure of ectodomain of bst-2/tetherin/cd317 (c2)
Structure deposition date
2010-04-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
24
Minimum pKa ?
9
% buried
0
Peptide A name
Bone marrow stromal antigen 2
Peptide B name
Bone marrow stromal antigen 2
Peptide A accession
Q10589
Peptide B accession
Q10589
Peptide A residue number
53
Peptide B residue number
53

Ligandability

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