ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kinesin-like protein KIF1A

Intramolecular
Cysteine 541 and cysteine 560
Cysteine 92 and cysteine 356
A redox-regulated disulphide may form within Kinesin-like protein KIF1A between cysteines 541 and 560. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
4egx
Structure name
crystal structure of kif1a cc1-fha tandem
Structure deposition date
2012-04-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
68
Peptide accession
Q12756
Residue number A
541
Residue number B
560
Peptide name
Kinesin-like protein KIF1A

Ligandability

Cysteine 541 of Kinesin-like protein KIF1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 560 of Kinesin-like protein KIF1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin-like protein KIF1A between cysteines 92 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7eo9
Structure name
crystal structure of kif1a motor-neck domain with adp-mg-alfx
Structure deposition date
2021-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
84
Peptide accession
P33173
Residue number A
92
Residue number B
356
Peptide name
Kinesin-like protein KIF1A

Ligandability

Cysteine 92 of Kinesin-like protein KIF1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Kinesin-like protein KIF1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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