ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sterol regulatory element-binding protein cleavage-activating protein

Intramolecular
Cysteine 36 and cysteine 40
Cysteine 40 and cysteine 41
Cysteine 40 and cysteine 334
A redox-regulated disulphide may form within Sterol regulatory element-binding protein cleavage-activating protein between cysteines 36 and 40.

Details

Redox score ?
60
PDB code
6m49
Structure name
cryo-em structure of scap/insig complex in the present of 25-hydroxyl cholesterol
Structure deposition date
2020-03-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
22
Peptide accession
Q12770
Residue number A
36
Residue number B
40
Peptide name
Sterol regulatory element-binding protein cleavage-activating protein

Ligandability

Cysteine 36 of Sterol regulatory element-binding protein cleavage-activating protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Sterol regulatory element-binding protein cleavage-activating protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sterol regulatory element-binding protein cleavage-activating protein between cysteines 40 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7etw
Structure name
cryo-em structure of scap/insig complex in the present of digitonin
Structure deposition date
2021-05-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
28
Peptide accession
Q12770
Residue number A
40
Residue number B
41
Peptide name
Sterol regulatory element-binding protein cleavage-activating protein

Ligandability

Cysteine 40 of Sterol regulatory element-binding protein cleavage-activating protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Sterol regulatory element-binding protein cleavage-activating protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sterol regulatory element-binding protein cleavage-activating protein between cysteines 40 and 334. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6m49
Structure name
cryo-em structure of scap/insig complex in the present of 25-hydroxyl cholesterol
Structure deposition date
2020-03-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
32
Peptide accession
Q12770
Residue number A
40
Residue number B
334
Peptide name
Sterol regulatory element-binding protein cleavage-activating protein

Ligandability

Cysteine 40 of Sterol regulatory element-binding protein cleavage-activating protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 334 of Sterol regulatory element-binding protein cleavage-activating protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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