ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Twinfilin-1

Intermolecular
Cysteine 42 and cysteine 42
A redox-regulated disulphide may form between two units of Twinfilin-1 at cysteines 42 and 42. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
1m4j
Structure name
crystal structure of the n-terminal adf-h domain of mouse twinfilin isoform-1
Structure deposition date
2002-07-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
99
Peptide A name
Twinfilin-1
Peptide B name
Twinfilin-1
Peptide A accession
Q91YR1
Peptide B accession
Q91YR1
Peptide A residue number
42
Peptide B residue number
42

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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