ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Aspartyl/asparaginyl beta-hydroxylase

Intramolecular
Cysteine 641 and cysteine 648
Cysteine 660 and cysteine 685
A redox-regulated disulphide may form within Aspartyl/asparaginyl beta-hydroxylase between cysteines 641 and 648.

Details

Redox score ?
84
PDB code
5jz6
Structure name
aspartyl/asparaginyl beta-hydroxylase (asph)oxygenase and tpr domains in complex with manganese and l-malate
Structure deposition date
2016-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q12797
Residue number A
641
Residue number B
648
Peptide name
Aspartyl/asparaginyl beta-hydroxylase

Ligandability

Cysteine 641 of Aspartyl/asparaginyl beta-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 648 of Aspartyl/asparaginyl beta-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aspartyl/asparaginyl beta-hydroxylase between cysteines 660 and 685. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6q9f
Structure name
aspartyl/asparaginyl beta-hydroxylase (asph) h679a in complex with mn, nog and factor x peptide fragment (39mer-4ser)
Structure deposition date
2018-12-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
10
% buried
88
Peptide accession
Q12797
Residue number A
660
Residue number B
685
Peptide name
Aspartyl/asparaginyl beta-hydroxylase

Ligandability

Cysteine 660 of Aspartyl/asparaginyl beta-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 685 of Aspartyl/asparaginyl beta-hydroxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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