a tool for identifying drug-targetable redox-active disulphides

A-kinase anchor protein 13

Intramolecular

Cysteine 2041 and cysteine 2101 L

A redox-regulated disulphide may form within A-kinase anchor protein 13 between cysteines 2041 and 2101 (2045 and 2105 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

28

PDB code

Structure name

akap13 (akap-lbc) rhogef domain in complex with rhoa

Structure deposition date

2014-04-29

Thiol separation (Å)

10

Half-sphere exposure sum ?

80

Minimum pK_a ?

11

% buried

76

Peptide accession

Residue number A

2041

Residue number B

2101

Peptide name

A-kinase anchor protein 13

Ligandability

Cysteine 2041 of A-kinase anchor protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2101 of A-kinase anchor protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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