a tool for identifying drug-targetable redox-active disulphides

Splicing factor 3A subunit 3

Intramolecular

Cysteine 408 and cysteine 411 L

A redox-regulated disulphide may form within Splicing factor 3A subunit 3 between cysteines 408 and 411.

Details

Redox score ?

77

PDB code

Structure name

human 17s u2 snrnp 5' domain

Structure deposition date

2021-10-28

Thiol separation (Å)

3

Half-sphere exposure sum ?

61

Minimum pK_a ?

10

% buried

nan

Peptide accession

Residue number A

408

Residue number B

411

Peptide name

Splicing factor 3A subunit 3

Ligandability

Cysteine 408 of Splicing factor 3A subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 411 of Splicing factor 3A subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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