ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin enhancer-binding factor 2

Intermolecular
Cysteine 37 and cysteine 278 of Interleukin enhancer-binding factor 3
A redox-regulated disulphide may form between cysteine 37 of Interleukin enhancer-binding factor 2 and cysteine 278 of Interleukin enhancer-binding factor 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4at7
Structure name
crystal structure of the nf90-nf45 dimerisation domain complex
Structure deposition date
2012-05-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
87
Peptide A name
Interleukin enhancer-binding factor 2
Peptide B name
Interleukin enhancer-binding factor 3
Peptide A accession
Q9CXY6
Peptide B accession
Q9Z1X4
Peptide A residue number
37
Peptide B residue number
278

Ligandability

Cysteine 37 of Interleukin enhancer-binding factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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