ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin enhancer-binding factor 3

Intermolecular
Cysteine 37 of Interleukin enhancer-binding factor 2 and cysteine 278
Intramolecular
Cysteine 226 and cysteine 255
Cysteine 116 and cysteine 203 L
Cysteine 237 and cysteine 255
Cysteine 255 and cysteine 278
A redox-regulated disulphide may form between cysteine 37 of Interleukin enhancer-binding factor 2 and cysteine 278 of Interleukin enhancer-binding factor 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4at7
Structure name
crystal structure of the nf90-nf45 dimerisation domain complex
Structure deposition date
2012-05-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
87
Peptide A name
Interleukin enhancer-binding factor 2
Peptide B name
Interleukin enhancer-binding factor 3
Peptide A accession
Q9CXY6
Peptide B accession
Q9Z1X4
Peptide A residue number
37
Peptide B residue number
278

Ligandability

Cysteine 37 of Interleukin enhancer-binding factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin enhancer-binding factor 3 between cysteines 226 and 255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4atb
Structure name
crystal structure of the nf90-nf45 dimerisation domain complex with ctp
Structure deposition date
2012-05-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
Q9Z1X4
Residue number A
226
Residue number B
255
Peptide name
Interleukin enhancer-binding factor 3

Ligandability

Cysteine 226 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin enhancer-binding factor 3 between cysteines 116 and 203. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4atb
Structure name
crystal structure of the nf90-nf45 dimerisation domain complex with ctp
Structure deposition date
2012-05-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
67
Peptide accession
Q9Z1X4
Residue number A
116
Residue number B
203
Peptide name
Interleukin enhancer-binding factor 3

Ligandability

Cysteine 116 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin enhancer-binding factor 3 between cysteines 237 and 255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4atb
Structure name
crystal structure of the nf90-nf45 dimerisation domain complex with ctp
Structure deposition date
2012-05-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
90
Peptide accession
Q9Z1X4
Residue number A
237
Residue number B
255
Peptide name
Interleukin enhancer-binding factor 3

Ligandability

Cysteine 237 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin enhancer-binding factor 3 between cysteines 255 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
4atb
Structure name
crystal structure of the nf90-nf45 dimerisation domain complex with ctp
Structure deposition date
2012-05-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
Q9Z1X4
Residue number A
255
Residue number B
278
Peptide name
Interleukin enhancer-binding factor 3

Ligandability

Cysteine 255 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Interleukin enhancer-binding factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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