ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Killer cell lectin-like receptor subfamily B member 1

Intramolecular
Cysteine 94 and cysteine 105
Cysteine 189 and cysteine 202
Cysteine 122 and cysteine 210
A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily B member 1 between cysteines 94 and 105.

Details

Redox score ?
85
PDB code
5mgs
Structure name
human receptor nkr-p1 in deglycosylated form, extracellular domain
Structure deposition date
2016-11-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q12918
Residue number A
94
Residue number B
105
Peptide name
Killer cell lectin-like receptor subfamily B member 1

Ligandability

Cysteine 94 of Killer cell lectin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Killer cell lectin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily B member 1 between cysteines 189 and 202.

Details

Redox score ?
84
PDB code
5mgt
Structure name
complex of human nkr-p1 and llt1 in deglycosylated forms
Structure deposition date
2016-11-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q12918
Residue number A
189
Residue number B
202
Peptide name
Killer cell lectin-like receptor subfamily B member 1

Ligandability

Cysteine 189 of Killer cell lectin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Killer cell lectin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily B member 1 between cysteines 122 and 210.

Details

Redox score ?
78
PDB code
5mgr
Structure name
human receptor nkr-p1 in glycosylated form, extracellular domain
Structure deposition date
2016-11-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q12918
Residue number A
122
Residue number B
210
Peptide name
Killer cell lectin-like receptor subfamily B member 1

Ligandability

Cysteine 122 of Killer cell lectin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Killer cell lectin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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