ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein phosphatase non-receptor type 13

Intramolecular
Cysteine 2420 and cysteine 2460
Cysteine 2319 and cysteine 2408
Cysteine 798 and cysteine 1467
Cysteine 2282 and cysteine 2408
Cysteine 2282 and cysteine 2319
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 13 between cysteines 2420 and 2460.

Details

Redox score ?
68
PDB code
1wch
Structure name
crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Structure deposition date
2004-11-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
88
Minimum pKa ?
9
% buried
100
Peptide accession
Q12923
Residue number A
2420
Residue number B
2460
Peptide name
Tyrosine-protein phosphatase non-receptor type 13

Ligandability

Cysteine 2420 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2460 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 13 between cysteines 2319 and 2408. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1wch
Structure name
crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Structure deposition date
2004-11-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
100
Peptide accession
Q12923
Residue number A
2319
Residue number B
2408
Peptide name
Tyrosine-protein phosphatase non-receptor type 13

Ligandability

Cysteine 2319 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2408 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 13 between cysteines 798 and 1467 (22 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2m0z
Structure name
cis form of a photoswitchable pdz domain crosslinked with an azobenzene derivative
Structure deposition date
2012-11-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
12
Peptide accession
Q12923
Residue number A
798
Residue number B
1467
Peptide name
Tyrosine-protein phosphatase non-receptor type 13

Ligandability

Cysteine 798 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1467 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 77 has been assigned to correct residue.
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 13 between cysteines 2282 and 2408. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1wch
Structure name
crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Structure deposition date
2004-11-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
99
Minimum pKa ?
9
% buried
100
Peptide accession
Q12923
Residue number A
2282
Residue number B
2408
Peptide name
Tyrosine-protein phosphatase non-receptor type 13

Ligandability

Cysteine 2282 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2408 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 13 between cysteines 2282 and 2319. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
1wch
Structure name
crystal structure of ptpl1 human tyrosine phosphatase mutated in colorectal cancer - evidence for a second phosphotyrosine substrate recognition pocket
Structure deposition date
2004-11-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q12923
Residue number A
2282
Residue number B
2319
Peptide name
Tyrosine-protein phosphatase non-receptor type 13

Ligandability

Cysteine 2282 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2319 of Tyrosine-protein phosphatase non-receptor type 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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