a tool for identifying drug-targetable redox-active disulphides

Heat shock protein 75 kDa, mitochondrial

Intramolecular

Cysteine 501 and cysteine 527

A redox-regulated disulphide may form within Heat shock protein 75 kDa, mitochondrial between cysteines 501 and 527.

Details

Redox score ?

67

PDB code

Structure name

structure of trap1 fragment

Structure deposition date

2016-01-20

Thiol separation (Å)

4

Half-sphere exposure sum ?

72

Minimum pK_a ?

9

% buried

84

Peptide accession

Residue number A

501

Residue number B

527

Peptide name

Heat shock protein 75 kDa, mitochondrial

Ligandability

Cysteine 501 of Heat shock protein 75 kDa, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 527 of Heat shock protein 75 kDa, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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