TNF receptor-associated factor 2
Intermolecular
Cysteine 303 and cysteine 303
Cysteine 272 and cysteine 272
Cysteine 287 and cysteine 287 L
Intramolecular
Cysteine 112 and cysteine 129
Cysteine 107 and cysteine 129
Cysteine 34 and cysteine 37 L
Cysteine 34 and cysteine 57 L
Cysteine 69 and cysteine 72
Cysteine 34 and cysteine 54 L
Cysteine 49 and cysteine 69
More...Cysteine 107 and cysteine 112
Cysteine 49 and cysteine 72
Cysteine 37 and cysteine 57 L
Cysteine 37 and cysteine 54 L
Cysteine 54 and cysteine 57
3m06 A 303 B 303
A redox-regulated disulphide may form between two units of TNF receptor-associated factor 2 at cysteines 303 and 303.
Details
Redox score ?
77
PDB code
3m06
Structure name
crystal structure of traf2
Structure deposition date
2010-03-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
20
Peptide A name
TNF receptor-associated factor 2
Peptide B name
TNF receptor-associated factor 2
Peptide A accession
Q12933
Peptide B accession
Q12933
Peptide A residue number
303
Peptide B residue number
303
Ligandability
3m06 B 272 C 272
A redox-regulated disulphide may form between two units of TNF receptor-associated factor 2 at cysteines 272 and 272.
Details
Redox score ?
70
PDB code
3m06
Structure name
crystal structure of traf2
Structure deposition date
2010-03-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
0
Peptide A name
TNF receptor-associated factor 2
Peptide B name
TNF receptor-associated factor 2
Peptide A accession
Q12933
Peptide B accession
Q12933
Peptide A residue number
272
Peptide B residue number
272
Ligandability
3m06 A 287 E 287
A redox-regulated disulphide may form between two units of TNF receptor-associated factor 2 at cysteines 287 and 287. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
3m06
Structure name
crystal structure of traf2
Structure deposition date
2010-03-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
51
Peptide A name
TNF receptor-associated factor 2
Peptide B name
TNF receptor-associated factor 2
Peptide A accession
Q12933
Peptide B accession
Q12933
Peptide A residue number
287
Peptide B residue number
287
Ligandability
3knv A 112 A 129
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 112 and 129.
Details
Redox score ?
90
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
5
% buried
0
Peptide accession
Q12933
Residue number A
112
Residue number B
129
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 112 of TNF receptor-associated factor 2
Cysteine 129 of TNF receptor-associated factor 2
3knv A 107 A 129
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 107 and 129.
Details
Redox score ?
88
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
6
Peptide accession
Q12933
Residue number A
107
Residue number B
129
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 107 of TNF receptor-associated factor 2
Cysteine 129 of TNF receptor-associated factor 2
3knv A 34 A 37
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 34 and 37.
Details
Redox score ?
86
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
3
% buried
48
Peptide accession
Q12933
Residue number A
34
Residue number B
37
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 34 of TNF receptor-associated factor 2
Cysteine 37 of TNF receptor-associated factor 2
3knv A 34 A 57
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 34 and 57.
Details
Redox score ?
86
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
3
% buried
46
Peptide accession
Q12933
Residue number A
34
Residue number B
57
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 34 of TNF receptor-associated factor 2
Cysteine 57 of TNF receptor-associated factor 2
3knv A 69 A 72
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 69 and 72.
Details
Redox score ?
85
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
22
Peptide accession
Q12933
Residue number A
69
Residue number B
72
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 69 of TNF receptor-associated factor 2
Cysteine 72 of TNF receptor-associated factor 2
3knv A 34 A 54
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 34 and 54.
Details
Redox score ?
84
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
3
% buried
62
Peptide accession
Q12933
Residue number A
34
Residue number B
54
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 34 of TNF receptor-associated factor 2
Cysteine 54 of TNF receptor-associated factor 2
3knv A 49 A 69
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 49 and 69.
Details
Redox score ?
83
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
37
Peptide accession
Q12933
Residue number A
49
Residue number B
69
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 49 of TNF receptor-associated factor 2
Cysteine 69 of TNF receptor-associated factor 2
3knv A 107 A 112
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 107 and 112.
Details
Redox score ?
82
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
6
Peptide accession
Q12933
Residue number A
107
Residue number B
112
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 107 of TNF receptor-associated factor 2
Cysteine 112 of TNF receptor-associated factor 2
3knv A 49 A 72
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 49 and 72.
Details
Redox score ?
78
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
20
Peptide accession
Q12933
Residue number A
49
Residue number B
72
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 49 of TNF receptor-associated factor 2
Cysteine 72 of TNF receptor-associated factor 2
3knv A 37 A 57
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 37 and 57.
Details
Redox score ?
76
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
34
Peptide accession
Q12933
Residue number A
37
Residue number B
57
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 37 of TNF receptor-associated factor 2
Cysteine 57 of TNF receptor-associated factor 2
3knv A 37 A 54
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 37 and 54.
Details
Redox score ?
73
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
50
Peptide accession
Q12933
Residue number A
37
Residue number B
54
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 37 of TNF receptor-associated factor 2
Cysteine 54 of TNF receptor-associated factor 2
3knv A 54 A 57
A redox-regulated disulphide may form within TNF receptor-associated factor 2 between cysteines 54 and 57.
Details
Redox score ?
66
PDB code
3knv
Structure name
crystal structure of the ring and first zinc finger domains of traf2
Structure deposition date
2009-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
49
Peptide accession
Q12933
Residue number A
54
Residue number B
57
Peptide name
TNF receptor-associated factor 2
Ligandability
Cysteine 54 of TNF receptor-associated factor 2
Cysteine 57 of TNF receptor-associated factor 2
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