a tool for identifying drug-targetable redox-active disulphides

Isoform 2 of Disks large homolog 1

Intramolecular

Cysteine 764 and cysteine 828

A redox-regulated disulphide may form within Isoform 2 of Disks large homolog 1 between cysteines 764 and 828.

Details

Redox score ?

72

PDB code

Structure name

crystal structure of the human dlg1 guanylate kinase domain

Structure deposition date

2013-04-18

Thiol separation (Å)

4

Half-sphere exposure sum ?

77

Minimum pK_a ?

8

% buried

84

Peptide accession

Residue number A

764

Residue number B

828

Peptide name

Isoform 2 of Disks large homolog 1

Ligandability

Cysteine 764 of Isoform 2 of Disks large homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 828 of Isoform 2 of Disks large homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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