a tool for identifying drug-targetable redox-active disulphides

Transcription initiation factor TFIID subunit 10

Intermolecular

Cysteine 173 of STAGA complex 65 subunit gamma and cysteine 174

A redox-regulated disulphide may form between cysteine 173 of STAGA complex 65 subunit gamma and cysteine 174 of Transcription initiation factor TFIID subunit 10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

cryo-em structure of the human saga complex

Structure deposition date

2022-10-20

Thiol separation (Å)

9

Half-sphere exposure sum ?

58

Minimum pK_a ?

10

% buried

29

Peptide A name

STAGA complex 65 subunit gamma

Peptide B name

Transcription initiation factor TFIID subunit 10

Peptide A accession

Peptide B accession

Peptide A residue number

173

Peptide B residue number

174

Ligandability

Cysteine 173 of STAGA complex 65 subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Transcription initiation factor TFIID subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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