ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein tyrosine phosphatase type IVA 2

Intramolecular
Cysteine 46 and cysteine 101
Cysteine 95 and cysteine 96
A redox-regulated disulphide may form within Protein tyrosine phosphatase type IVA 2 between cysteines 46 and 101.

Details

Redox score ?
81
PDB code
5k24
Structure name
crystal structure of the complex between phosphatase prl-2 in the oxidized state with the bateman domain of murine magnesium transporter cnnm3
Structure deposition date
2016-05-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O70274
Residue number A
46
Residue number B
101
Peptide name
Protein tyrosine phosphatase type IVA 2

Ligandability

Cysteine 46 of Protein tyrosine phosphatase type IVA 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Protein tyrosine phosphatase type IVA 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein tyrosine phosphatase type IVA 2 between cysteines 95 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5k25
Structure name
crystal structure of human phosphatase prl-2 in complex with the adp- bound bateman domain of human magnesium transporter cnnm3
Structure deposition date
2016-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
55
Peptide accession
Q12974
Residue number A
95
Residue number B
96
Peptide name
Protein tyrosine phosphatase type IVA 2

Ligandability

Cysteine 95 of Protein tyrosine phosphatase type IVA 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Protein tyrosine phosphatase type IVA 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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