ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GATOR complex protein NPRL3

Intermolecular
Cysteine 348 of GATOR complex protein NPRL2 and cysteine 343
Cysteine 286 of GATOR complex protein NPRL2 and cysteine 343
Cysteine 286 of GATOR complex protein NPRL2 and cysteine 411
A redox-regulated disulphide may form between cysteine 348 of GATOR complex protein NPRL2 and cysteine 343 of GATOR complex protein NPRL3.

Details

Redox score ?
62
PDB code
7t3c
Structure name
gator1-rag-ragulator - dual complex
Structure deposition date
2021-12-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
4
Peptide A name
GATOR complex protein NPRL2
Peptide B name
GATOR complex protein NPRL3
Peptide A accession
Q8WTW4
Peptide B accession
Q12980
Peptide A residue number
348
Peptide B residue number
343

Ligandability

Cysteine 348 of GATOR complex protein NPRL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of GATOR complex protein NPRL3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 286 of GATOR complex protein NPRL2 and cysteine 343 of GATOR complex protein NPRL3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
46
Peptide A name
GATOR complex protein NPRL2
Peptide B name
GATOR complex protein NPRL3
Peptide A accession
Q8WTW4
Peptide B accession
Q12980
Peptide A residue number
286
Peptide B residue number
343

Ligandability

Cysteine 286 of GATOR complex protein NPRL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of GATOR complex protein NPRL3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 286 of GATOR complex protein NPRL2 and cysteine 411 of GATOR complex protein NPRL3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7t3b
Structure name
gator1-rag-ragulator - gap complex
Structure deposition date
2021-12-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
90
Peptide A name
GATOR complex protein NPRL2
Peptide B name
GATOR complex protein NPRL3
Peptide A accession
Q8WTW4
Peptide B accession
Q12980
Peptide A residue number
286
Peptide B residue number
411

Ligandability

Cysteine 286 of GATOR complex protein NPRL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 411 of GATOR complex protein NPRL3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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