Glutamate receptor ionotropic, kainate 2
Intermolecular
Cysteine 230 and cysteine 22
Cysteine 595 and cysteine 595
Cysteine 83 of Glutamate receptor ionotropic, kainate 5 and cysteine 347
Cysteine 83 of Green fluorescent protein and cysteine 96
Cysteine 83 of Green fluorescent protein and cysteine 347
Cysteine 96 and cysteine 347
Cysteine 83 of Glutamate receptor ionotropic, kainate 5 and cysteine 96
Cysteine 96 and cysteine 96
Intramolecular
Cysteine 750 and cysteine 804
Cysteine 122 and cysteine 347
More...Cysteine 96 and cysteine 122
Cysteine 22 and cysteine 576
2i0c A 94 B 236
A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, kainate 2 at cysteines 230 and 22 (94 and 236 respectively in this structure).
Details
Redox score ?
81
PDB code
2i0c
Structure name
crystal structure of the glur6 ligand binding core dimer crosslinked by disulfide bonds between y490c and l752c at 2
Structure deposition date
2006-08-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 2
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
P42260
Peptide B accession
P42260
Peptide A residue number
230
Peptide B residue number
22
Ligandability
Cysteine 230 of Glutamate receptor ionotropic, kainate 2
Cysteine 22 of Glutamate receptor ionotropic, kainate 2
7f59 A 595 D 595
A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, kainate 2 at cysteines 595 and 595. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7f59
Structure name
dnqx-bound gluk2-1xneto2 complex
Structure deposition date
2021-06-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
27
Minimum pKa ?
9
% buried
0
Peptide A name
Glutamate receptor ionotropic, kainate 2
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
P42260
Peptide B accession
P42260
Peptide A residue number
595
Peptide B residue number
595
Ligandability
3qlv I 64 J 316
A redox-regulated disulphide may form between cysteine 83 of Glutamate receptor ionotropic, kainate 5 and cysteine 347 of Glutamate receptor ionotropic, kainate 2 (64 and 316 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3qlv
Structure name
crystal structure of the gluk2/gluk5 (glur6/ka2) atd tetramer assembly
Structure deposition date
2011-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 5
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
Q63273
Peptide B accession
P42260
Peptide A residue number
83
Peptide B residue number
347
Ligandability
Cysteine 83 of Glutamate receptor ionotropic, kainate 5
Cysteine 347 of Glutamate receptor ionotropic, kainate 2
7ks0 C 83 D 96
A redox-regulated disulphide may form between cysteine 83 of Green fluorescent protein and cysteine 96 of Glutamate receptor ionotropic, kainate 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7ks0
Structure name
gluk2/k5 with 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx)
Structure deposition date
2020-11-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide A name
Green fluorescent protein
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
P42212
Peptide B accession
P42260
Peptide A residue number
83
Peptide B residue number
96
Ligandability
Cysteine 83 of Green fluorescent protein
Cysteine 96 of Glutamate receptor ionotropic, kainate 2
Cysteine 83 in protein A could not be asigned to a Uniprot residue.
7ks0 A 83 B 347
A redox-regulated disulphide may form between cysteine 83 of Green fluorescent protein and cysteine 347 of Glutamate receptor ionotropic, kainate 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7ks0
Structure name
gluk2/k5 with 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx)
Structure deposition date
2020-11-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Green fluorescent protein
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
P42212
Peptide B accession
P42260
Peptide A residue number
83
Peptide B residue number
347
Ligandability
Cysteine 83 of Green fluorescent protein
Cysteine 347 of Glutamate receptor ionotropic, kainate 2
Cysteine 83 in protein A could not be asigned to a Uniprot residue.
3h6h A 65 B 316
A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, kainate 2 at cysteines 96 and 347 (65 and 316 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
3h6h
Structure name
crystal structure of the glur6 amino terminal domain dimer assembly mpd form
Structure deposition date
2009-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 2
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
P42260
Peptide B accession
P42260
Peptide A residue number
96
Peptide B residue number
347
Ligandability
Cysteine 96 of Glutamate receptor ionotropic, kainate 2
Cysteine 347 of Glutamate receptor ionotropic, kainate 2
3qlu B 64 D 65
A redox-regulated disulphide may form between cysteine 83 of Glutamate receptor ionotropic, kainate 5 and cysteine 96 of Glutamate receptor ionotropic, kainate 2 (64 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
3qlu
Structure name
crystal structure of the gluk2/gluk5 (glur6/ka2) atd dimer assembly
Structure deposition date
2011-02-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 5
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
Q63273
Peptide B accession
P42260
Peptide A residue number
83
Peptide B residue number
96
Ligandability
Cysteine 83 of Glutamate receptor ionotropic, kainate 5
Cysteine 96 of Glutamate receptor ionotropic, kainate 2
3h6g A 65 B 65
A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, kainate 2 at cysteines 96 and 96 (65 and 65 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
3h6g
Structure name
crystal structure of the glur6 amino terminal domain dimer assembly
Structure deposition date
2009-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 2
Peptide B name
Glutamate receptor ionotropic, kainate 2
Peptide A accession
P42260
Peptide B accession
P42260
Peptide A residue number
96
Peptide B residue number
96
Ligandability
7f57 D 750 D 804
A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 2 between cysteines 750 and 804. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7f57
Structure name
kainate-bound gluk2-1xneto2 complex, at the desensitized state
Structure deposition date
2021-06-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
P42260
Residue number A
750
Residue number B
804
Peptide name
Glutamate receptor ionotropic, kainate 2
Ligandability
Cysteine 750 of Glutamate receptor ionotropic, kainate 2
Cysteine 804 of Glutamate receptor ionotropic, kainate 2
3h6g B 91 B 316
A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 2 between cysteines 122 and 347 (91 and 316 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
3h6g
Structure name
crystal structure of the glur6 amino terminal domain dimer assembly
Structure deposition date
2009-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
nan
Peptide accession
P42260
Residue number A
122
Residue number B
347
Peptide name
Glutamate receptor ionotropic, kainate 2
Ligandability
Cysteine 122 of Glutamate receptor ionotropic, kainate 2
Cysteine 347 of Glutamate receptor ionotropic, kainate 2
3qlu D 65 D 91
A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 2 between cysteines 96 and 122 (65 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
3qlu
Structure name
crystal structure of the gluk2/gluk5 (glur6/ka2) atd dimer assembly
Structure deposition date
2011-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
nan
Peptide accession
P42260
Residue number A
96
Residue number B
122
Peptide name
Glutamate receptor ionotropic, kainate 2
Ligandability
Cysteine 96 of Glutamate receptor ionotropic, kainate 2
Cysteine 122 of Glutamate receptor ionotropic, kainate 2
7f57 C 571 C 576
A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 2 between cysteines 22 and 576 (571 and 576 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7f57
Structure name
kainate-bound gluk2-1xneto2 complex, at the desensitized state
Structure deposition date
2021-06-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
66
Peptide accession
P42260
Residue number A
22
Residue number B
576
Peptide name
Glutamate receptor ionotropic, kainate 2
Ligandability
Cysteine 22 of Glutamate receptor ionotropic, kainate 2
Cysteine 576 of Glutamate receptor ionotropic, kainate 2
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