ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glutamate receptor ionotropic, kainate 3

Intermolecular
Cysteine 350 and cysteine 99
Cysteine 350 and cysteine 350
Cysteine 99 and cysteine 99
Intramolecular
Cysteine 751 and cysteine 117
Cysteine 751 and cysteine 255
Cysteine 751 and cysteine 805
A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, kainate 3 at cysteines 350 and 99 (319 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6jfy
Structure name
gluk3 receptor trapped in desensitized state
Structure deposition date
2019-02-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 3
Peptide B name
Glutamate receptor ionotropic, kainate 3
Peptide A accession
P42264
Peptide B accession
P42264
Peptide A residue number
350
Peptide B residue number
99

Ligandability

Cysteine 350 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, kainate 3 at cysteines 350 and 350 (319 and 319 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7vm2
Structure name
gluk3 d759g mutant receptor complex with ubp310 and spermine
Structure deposition date
2021-10-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 3
Peptide B name
Glutamate receptor ionotropic, kainate 3
Peptide A accession
P42264
Peptide B accession
P42264
Peptide A residue number
350
Peptide B residue number
350

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Glutamate receptor ionotropic, kainate 3 at cysteines 99 and 99 (68 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7vm2
Structure name
gluk3 d759g mutant receptor complex with ubp310 and spermine
Structure deposition date
2021-10-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Glutamate receptor ionotropic, kainate 3
Peptide B name
Glutamate receptor ionotropic, kainate 3
Peptide A accession
P42264
Peptide B accession
P42264
Peptide A residue number
99
Peptide B residue number
99

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 3 between cysteines 751 and 117 (720 and 774 respectively in this structure).

Details

Redox score ?
88
PDB code
6jfy
Structure name
gluk3 receptor trapped in desensitized state
Structure deposition date
2019-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42264
Residue number A
751
Residue number B
117
Peptide name
Glutamate receptor ionotropic, kainate 3

Ligandability

Cysteine 751 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 774 has been assigned to correct residue.
A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 3 between cysteines 751 and 255 (201 and 255 respectively in this structure).

Details

Redox score ?
88
PDB code
3u93
Structure name
crystal structure of the gluk3 ligand binding domain complex with glutamate and zinc: p2221 form
Structure deposition date
2011-10-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P42264
Residue number A
751
Residue number B
255
Peptide name
Glutamate receptor ionotropic, kainate 3

Ligandability

Cysteine 751 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Glutamate receptor ionotropic, kainate 3 between cysteines 751 and 805 (720 and 774 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7vm2
Structure name
gluk3 d759g mutant receptor complex with ubp310 and spermine
Structure deposition date
2021-10-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P42264
Residue number A
751
Residue number B
805
Peptide name
Glutamate receptor ionotropic, kainate 3

Ligandability

Cysteine 751 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 805 of Glutamate receptor ionotropic, kainate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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