ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Interleukin-24

Intramolecular
Cysteine 59 and cysteine 59
Cysteine 59 and cysteine 106
A redox-regulated disulphide may form within Interleukin-24 between cysteines 59 and 59 (59 and 154 respectively in this structure).

Details

Redox score ?
85
PDB code
6gg1
Structure name
structure of pross-edited human interleukin 24
Structure deposition date
2018-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13007
Residue number A
59
Residue number B
59
Peptide name
Interleukin-24

Ligandability

Cysteine 59 of Interleukin-24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Interleukin-24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 154 has been assigned to correct residue.
A redox-regulated disulphide may form within Interleukin-24 between cysteines 59 and 106.

Details

Redox score ?
80
PDB code
6df3
Structure name
crystal structure of ternary complex of il-24 with soluble receptors il-22ra and il-20rb
Structure deposition date
2018-05-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
50
Peptide accession
Q13007
Residue number A
59
Residue number B
106
Peptide name
Interleukin-24

Ligandability

Cysteine 59 of Interleukin-24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Interleukin-24

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: