ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho GTPase-activating protein 5

Intramolecular
Cysteine 658 and cysteine 660
Cysteine 660 and cysteine 727
Cysteine 658 and cysteine 727
A redox-regulated disulphide may form within Rho GTPase-activating protein 5 between cysteines 658 and 660.

Details

Redox score ?
64
PDB code
5u4v
Structure name
pseudogtpase domain (pg1) of p190rhogap-b
Structure deposition date
2016-12-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
8
% buried
97
Peptide accession
Q13017
Residue number A
658
Residue number B
660
Peptide name
Rho GTPase-activating protein 5

Ligandability

Cysteine 658 of Rho GTPase-activating protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 660 of Rho GTPase-activating protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho GTPase-activating protein 5 between cysteines 660 and 727. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5u4v
Structure name
pseudogtpase domain (pg1) of p190rhogap-b
Structure deposition date
2016-12-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
83
Peptide accession
Q13017
Residue number A
660
Residue number B
727
Peptide name
Rho GTPase-activating protein 5

Ligandability

Cysteine 660 of Rho GTPase-activating protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 727 of Rho GTPase-activating protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho GTPase-activating protein 5 between cysteines 658 and 727. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5u4v
Structure name
pseudogtpase domain (pg1) of p190rhogap-b
Structure deposition date
2016-12-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
80
Peptide accession
Q13017
Residue number A
658
Residue number B
727
Peptide name
Rho GTPase-activating protein 5

Ligandability

Cysteine 658 of Rho GTPase-activating protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 727 of Rho GTPase-activating protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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