ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Secretory phospholipase A2 receptor

Intramolecular
Cysteine 1209 and cysteine 1223
Cysteine 1142 and cysteine 1232
A redox-regulated disulphide may form within Secretory phospholipase A2 receptor between cysteines 1209 and 1223.

Details

Redox score ?
84
PDB code
6jli
Structure name
crystal structure of ctld7 domain of human pla2r
Structure deposition date
2019-03-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13018
Residue number A
1209
Residue number B
1223
Peptide name
Secretory phospholipase A2 receptor

Ligandability

Cysteine 1209 of Secretory phospholipase A2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1223 of Secretory phospholipase A2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Secretory phospholipase A2 receptor between cysteines 1142 and 1232.

Details

Redox score ?
83
PDB code
6jli
Structure name
crystal structure of ctld7 domain of human pla2r
Structure deposition date
2019-03-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q13018
Residue number A
1142
Residue number B
1232
Peptide name
Secretory phospholipase A2 receptor

Ligandability

Cysteine 1142 of Secretory phospholipase A2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1232 of Secretory phospholipase A2 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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