ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TNF receptor-associated factor 1

Intramolecular
Cysteine 384 and cysteine 410
Cysteine 306 and cysteine 410
A redox-regulated disulphide may form within TNF receptor-associated factor 1 between cysteines 384 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
5h10
Structure name
traf1-tank complex
Structure deposition date
2016-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
84
Peptide accession
Q13077
Residue number A
384
Residue number B
410
Peptide name
TNF receptor-associated factor 1

Ligandability

Cysteine 384 of TNF receptor-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of TNF receptor-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TNF receptor-associated factor 1 between cysteines 306 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
5h10
Structure name
traf1-tank complex
Structure deposition date
2016-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
93
Peptide accession
Q13077
Residue number A
306
Residue number B
410
Peptide name
TNF receptor-associated factor 1

Ligandability

Cysteine 306 of TNF receptor-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of TNF receptor-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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