ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Acetyl-CoA carboxylase 1

Intramolecular
Cysteine 2074 and cysteine 2075
Cysteine 634 and cysteine 743
Cysteine 448 and cysteine 560
A redox-regulated disulphide may form within Acetyl-CoA carboxylase 1 between cysteines 2074 and 2075 (2111 and 2112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4asi
Structure name
crystal structure of human acaca c-terminal domain
Structure deposition date
2012-05-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
72
Peptide accession
Q13085
Residue number A
2074
Residue number B
2075
Peptide name
Acetyl-CoA carboxylase 1

Ligandability

Cysteine 2074 of Acetyl-CoA carboxylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2075 of Acetyl-CoA carboxylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acetyl-CoA carboxylase 1 between cysteines 634 and 743. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6g2d
Structure name
citrate-induced acetyl-coa carboxylase (acc-cit) filament at 5
Structure deposition date
2018-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
78
Peptide accession
Q13085
Residue number A
634
Residue number B
743
Peptide name
Acetyl-CoA carboxylase 1

Ligandability

Cysteine 634 of Acetyl-CoA carboxylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 743 of Acetyl-CoA carboxylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acetyl-CoA carboxylase 1 between cysteines 448 and 560. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6g2d
Structure name
citrate-induced acetyl-coa carboxylase (acc-cit) filament at 5
Structure deposition date
2018-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q13085
Residue number A
448
Residue number B
560
Peptide name
Acetyl-CoA carboxylase 1

Ligandability

Cysteine 448 of Acetyl-CoA carboxylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 560 of Acetyl-CoA carboxylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: