ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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COP9 signalosome complex subunit 1

Intramolecular
Cysteine 192 and cysteine 202
Cysteine 251 and cysteine 278
Cysteine 251 and cysteine 269
Cysteine 175 and cysteine 184
Cysteine 269 and cysteine 296
A redox-regulated disulphide may form within COP9 signalosome complex subunit 1 between cysteines 192 and 202 (228 and 238 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4d10
Structure name
crystal structure of the cop9 signalosome
Structure deposition date
2014-04-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
40
Peptide accession
Q13098
Residue number A
192
Residue number B
202
Peptide name
COP9 signalosome complex subunit 1

Ligandability

Cysteine 192 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within COP9 signalosome complex subunit 1 between cysteines 251 and 278 (287 and 314 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6r7n
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
72
Peptide accession
Q13098
Residue number A
251
Residue number B
278
Peptide name
COP9 signalosome complex subunit 1

Ligandability

Cysteine 251 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within COP9 signalosome complex subunit 1 between cysteines 251 and 269 (287 and 305 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4d10
Structure name
crystal structure of the cop9 signalosome
Structure deposition date
2014-04-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
76
Peptide accession
Q13098
Residue number A
251
Residue number B
269
Peptide name
COP9 signalosome complex subunit 1

Ligandability

Cysteine 251 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within COP9 signalosome complex subunit 1 between cysteines 175 and 184. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6r7f
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
56
Peptide accession
Q13098
Residue number A
175
Residue number B
184
Peptide name
COP9 signalosome complex subunit 1

Ligandability

Cysteine 175 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within COP9 signalosome complex subunit 1 between cysteines 269 and 296 (305 and 332 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6r6h
Structure name
structural basis of cullin-2 ring e3 ligase regulation by the cop9 signalosome
Structure deposition date
2019-03-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
75
Peptide accession
Q13098
Residue number A
269
Residue number B
296
Peptide name
COP9 signalosome complex subunit 1

Ligandability

Cysteine 269 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of COP9 signalosome complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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